The Division of Experimental Medicine at the University of California, San Francisco was established to diagnose, prevent, and treat chronic infectious disease of global importance. Through a multidisciplinary and collaborative research approach, we study the way in which the human body responds to infectious agents that can co-infect the same host, e.g., HIV, tuberculosis, malaria, and helminthic worms. Each of these agents has a unique impact on the human immune system and studying them individually as well as in concert presents a more complete understanding of underlying disease. We believe our approach will lead to the development of vaccines and eventually the eradication of these diseases around the world.