Jayant Rajan, MD, PhD

Assistant Professor

I am an infectious diseases physician by training with a background in immunology, epidemiology/biostatistics and computation. My research is largely translational with my primary focus being the use of unbiased serological profiling to understand the humoral immune response to flavivirus infections. I believe that this approach, combined with others can aid us in vaccine design. I am also interested in expanding this technique to other infectious diseases.

My second area of interest is more computation-focused. In collaboration with other investigators at UCSF, I have developed a gene expression signature that we believe can be an effective tool for TB-screening in people with HIV in TB-endemic areas. This work fits into a larger interest in trying to understand how to more effectively leverage data generated from high throughput assays.
Education
PhD, 2016 - Epidemiology, University of California, Berkeley
MA, 2015 - Biostatistics, University of California, Berkeley
06/2011 - Fellowship, Infectious Diseases, University of Washington
06/2006 - Residency, Internal Medicine, University of Washington
MD, 2003 - Medicine, University of Rochester
AB, 1994 - Biology/Anthropology, Amherst College
Publications
  1. Sabatino JJ, Mittl K, Rowles WM, McPolin K, Rajan JV, Laurie MT, Zamecnik CR, Dandekar R, Alvarenga BD, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Augusto DG, Alexander JR, DeRisi JL, Hollenbach JA, Wilson MR, Zamvil SS, Bove R. Multiple sclerosis therapies differentially impact SARS-CoV-2 vaccine-induced antibody and T cell immunity and function. 2022. PMID: 35030101


  2. Sabatino JJ, Mittl K, Rowles W, Mcpolin K, Rajan JV, Zamecnik CR, Dandekar R, Alvarenga BD, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Augusto DG, Alexander J, Hollenbach JA, Wilson MR, Zamvil SS, Bove R. Impact of multiple sclerosis disease-modifying therapies on SARS-CoV-2 vaccine-induced antibody and T cell immunity. 2021. PMID: 34580672


  3. Rajan JV, McCracken M, Mandel-Brehm C, Gromowski G, Pollett S, Jarman R, DeRisi JL. Phage display demonstrates durable differences in serological profile by route of inoculation in primary infections of non-human primates with Dengue Virus 1. 2021. PMID: 34031504


  4. Zamecnik CR, Rajan JV, Yamauchi KA, Mann SA, Loudermilk RP, Sowa GM, Zorn KC, Alvarenga BD, Gaebler C, Caskey M, Stone M, Norris PJ, Gu W, Chiu CY, Ng D, Byrnes JR, Zhou XX, Wells JA, Robbiani DF, Nussenzweig MC, DeRisi JL, Wilson MR. ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens. 2020. PMID: 32995758


  5. Rajan JV, Semitala FC, Mehta T, Seielstad M, Montalvo L, Andama A, Asege L, Nakaye M, Katende J, Mwebe S, Kamya MR, Yoon C, Cattamanchi A. A Novel, 5-Transcript, Whole-blood Gene-expression Signature for Tuberculosis Screening Among People Living With Human Immunodeficiency Virus. 2019. PMID: 30462176


  6. Prado TND, Riley LW, Sanchez M, Fregona G, Nóbrega RLP, Possuelo LG, Zandonade E, Locatelli RL, Souza FM, Rajan JV, Maciel ELN. Prevalence and risk factors for latent tuberculosis infection among primary health care workers in Brazil. 2017. PMID: 29267691


  7. Snyder RE, Rajan JV, Costa F, Lima HCAV, Calcagno JI, Couto RD, Riley LW, Reis MG, Ko AI, Ribeiro GS. Differences in the Prevalence of Non-Communicable Disease between Slum Dwellers and the General Population in a Large Urban Area in Brazil. 2017. PMID: 30270904


  8. Rajan JV, Ferrazoli L, Waldman EA, Simonsen V, Ferreira P, Telles MA, Riley LW. Diabetes increases the risk of recent-transmission tuberculosis in household contacts in São Paulo, Brazil. 2017. PMID: 28786800


  9. Prado TN, Rajan JV, Miranda AE, Dias ED, Cosme LB, Possuelo LG, Sanchez MN, Golub JE, Riley LW, Maciel EL. Clinical and epidemiological characteristics associated with unfavorable tuberculosis treatment outcomes in TB-HIV co-infected patients in Brazil: a hierarchical polytomous analysis. 2016. PMID: 27936379


  10. Rajan JV, Moura J, Gourley G, Kiso K, Sizilio A, Cortez AM, Riley LW, Veras MA, Sarkar U. Understanding the barriers to successful adoption and use of a mobile health information system in a community health center in São Paulo, Brazil: a cohort study. 2016. PMID: 27855685