The Journal of experimental medicine
Authors: Beck-Engeser GB, Monach PA, Mumberg D, Yang F, Wanderling S, Schreiber K, Espinosa R, Le Beau MM, Meredith SC, Schreiber H
The Journal of biological chemistry | Volume 276 of Issue 37
Authors: Sonda S, Ting LM, Novak S, Kim K, Maher JJ, Farese RV, Ernst JD
Upon host cell invasion the apicomplexan parasite Toxoplasma gondii resides in a specialized compartment termed the parasitophorous vacuole that is derived from the host cell membrane but modified by the parasite. Despite the segregation of the parasitophorous vacuole from the host endocytic network, the intravacuolar parasite has been shown to acquire cholesterol from the host cell. In order to characterize further the role of sterol metabolism in T. gondii biology, we focused our studies on the activity of acyl-CoA:cholesterol acyltransferase (ACAT), a key enzyme for maintaining the intracellular homeostasis of cholesterol through the formation of cholesterol esters. In this study, we demonstrate that ACAT and cholesterol esters play a crucial role in the optimal replication of T. gondii. Moreover, we identified ACAT activity in T. gondii that can be modulated by pharmacological ACAT inhibitors with a consequent detrimental effect on parasite replication.
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A Phenomenological Study of Lesbian and Gay People in Leadership Roles: How Perspectives and Priorities Shift in the Workplace a Sexual Orientation Evolves through Social Constructs (Doctoral dissertation)
Authors: Sonda S, Ting LM, Novak S, Kim K, Maher JJ, Farese RV, Ernst JD
TO REMOVE
Authors: Peters W, Scott HM, Chambers HF, Flynn JL, Charo IF, Ernst JD
A Phenomenological Study of Lesbian and Gay People in Leadership Roles: How Perspectives and Priorities Shift in the Workplace a Sexual Orientation Evolves through Social Constructs (Doctoral dissertation)
Authors: Peters W, Scott HM, Chambers HF, Flynn JL, Charo IF, Ernst JD
AIDS (London, England)
Authors: García F, Plana M, Ortiz GM, Bonhoeffer S, Soriano A, Vidal C, Cruceta A, Arnedo M, Gil C, Pantaleo G, Pumarola T, Gallart T, Nixon DF, Miró JM, Gatell JM
Nature medicine
Authors: Stoddart CA, Liegler TJ, Mammano F, Linquist-Stepps VD, Hayden MS, Deeks SG, Grant RM, Clavel F, McCune JM
Nature
Authors: McCune JM
The Journal of infectious diseases
Authors: Jacobson MA, Schrier R, McCune JM, Torriani FJ, Holland GN, O'Donnell JJ, Freeman WR, Bredt BM
American journal of epidemiology
Authors: Peluso M, Ceppi M, Munnia A, Puntoni R, Parodi S