Since starting her career in Tübingen, Gabriele moved to Hamburg and worked with Dr.Wolfram Ostertag at the Heinrich Pette Institute, University of Hamburg, Germany. Gabriele was involved in the regulation of hematopoietic cell proliferation and in the construction and testing of retroviral vectors for gene transfer into hematopoietic stem and precursor cells.
After Hamburg, Gabriele joined the laboratory of Dr. Hans-Martin Jäck at Loyola University Chicago Medical Center, USA. Gabriele helped Dr. Jäck to establish his laboratory and to start a new project dealing with the mechanisms of early B cell development. This gave her the opportunity to expand her abilities not only to work independently on her own projects, but also to teach graduate students and furthermore to organize the daily operation of Dr.Jäck's laboratory, which included supervising lab technicians, budget management and ordering of supplies.
After Dr. Jäck moved back to Germany Gabriele held a senior research specialist position in the tumor immunology laboratory of Dr. Hans Schreiber at the University of Chicago. Here she was involved in designing inducible vectors applying the cre-lox system and studied the synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors.
In 2006 Gabriele joined again the laboratory of Dr. Matthias Wabl. This time at the University of California, San Francisco (UCSF) studying B lymphocyte differentiation and the mutations that result in lymphomas and later the cause of systemic lupus erythematosus. In her day-to-day work, Gabriele planned and carried out most of the experiments, has been in charge of the mouse colony, oversaw the breeding and typing of the various strains of mice and served as lab manager.
In 2017 Gabriele joined the laboratory of Dr. Peter Hunt in the Department of Medicine, Division of Experimental Medicine, at UCSF. Gabriele performs assays on human cells and tissues including isolation and flow cytometry-based phenotyping of peripheral blood mononuclear cells, cell culture with stimulation and intracellular cytokine staining, cell proliferation assays, as well as ELISA-based plasma assays.
Gabriele co-authored 30 publications.
When not in the laboratory, Gabriele supports several outreach programs for homeless people in San Francisco, listens to Jazz and Blues music and is an avid reader.
Peluso MJ, Deveau TM, Munter SE, Ryder DM, Buck AM, Beck-Engeser G, Chan F, Lu S, Goldberg SA, Hoh R, Tai V, Torres L, Iyer NS, Deswal M, Ngo LH, Buitrago M, Rodriguez AE, Chen JY, Yee BC, Chenna A, Winslow JW, Petropoulos CJ, Deitchman AN, Hellmuth J, Spinelli MA, Durstenfeld MS, Hsue PY, Kelly JD, Martin JN, Deeks SG, Hunt PW, Henrich TJ. Impact of pre-existing chronic viral infection and reactivation on the development of long COVID. The Journal of clinical investigation 2022. PMID: 36454631
Peluso MJ, Deveau TM, Munter SE, Ryder D, Buck A, Beck-Engeser G, Chan F, Lu S, Goldberg SA, Hoh R, Tai V, Torres L, Iyer NS, Deswal M, Ngo LH, Buitrago M, Rodriguez A, Chen JY, Yee BC, Chenna A, Winslow JW, Petropoulos CJ, Deitchman AN, Hellmuth J, Spinelli MA, Durstenfeld MS, Hsue PY, Kelly JD, Martin JN, Deeks SG, Hunt PW, Henrich TJ. Impact of Pre-Existing Chronic Viral Infection and Reactivation on the Development of Long COVID. medRxiv : the preprint server for health sciences 2022. PMID: 35898346
Riley ED, Kizer JR, Tien PC, Vittinghoff E, Lynch KL, Wu AHB, Coffin PO, Beck-Engeser G, Braun C, Hunt PW. Multiple substance use, inflammation and cardiac stretch in women living with HIV. Drug and alcohol dependence 2022. PMID: 35872529
Schnittman SR, Deitchman AN, Beck-Engeser G, Ahn H, York VA, Hartig H, Hecht FM, Martin JN, Deeks SG, Aweeka FT, Hunt PW. Abnormal Levels of Some Biomarkers of Immune Activation Despite Very Early Treatment of Human Immunodeficiency Virus. The Journal of infectious diseases 2021. PMID: 32915986
Böttinger P, Schreiber K, Hyjek E, Krausz T, Spiotto MT, Steiner M, Idel C, Booras H, Beck-Engeser G, Riederer J, Willimsky G, Wolf SP, Karrison T, Jensen E, Weichselbaum RR, Nakamura Y, Yew PY, Lambert PF, Kurita T, Kiyotani K, Leisegang M, Schreiber H. Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens. Carcinogenesis 2020. PMID: 32221533
Beck-Engeser GB, Ahrends T, Knittel G, Wabl R, Metzner M, Eilat D, Wabl M. Infectivity and insertional mutagenesis of endogenous retrovirus in autoimmune NZB and B/W mice. The Journal of general virology 2015. PMID: 26315139
Beck-Engeser GB, Winkelmann R, Wheeler ML, Shansab M, Yu P, Wünsche S, Walchhütter A, Metzner M, Vettermann C, Eilat D, DeFranco A, Jäck HM, Wabl M. APOBEC3 enzymes restrict marginal zone B cells. European journal of immunology 2015. PMID: 25501566
Knittel G, Metzner M, Beck-Engeser G, Kan A, Ahrends T, Eilat D, Huppi K, Wabl M. Insertional hypermutation in mineral oil-induced plasmacytomas. European journal of immunology 2014. PMID: 24975032
Beck-Engeser GB, Eilat D, Wabl M. An autoimmune disease prevented by anti-retroviral drugs. Retrovirology 2011. PMID: 22067273
Lum AM, Wang BB, Beck-Engeser GB, Li L, Channa N, Wabl M. Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer. BMC cancer 2010. PMID: 20149256
Beck-Engeser GB, Eilat D, Harrer T, Jäck HM, Wabl M. Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir. Proceedings of the National Academy of Sciences of the United States of America 2009. PMID: 19923437
Schaller CE, Wang CL, Beck-Engeser G, Goss L, Scott HS, Anderson MS, Wabl M. Expression of Aire and the early wave of apoptosis in spermatogenesis. Journal of immunology (Baltimore, Md. : 1950) 2008. PMID: 18209027
Beck-Engeser GB, Lum AM, Huppi K, Caplen NJ, Wang BB, Wabl M. Pvt1-encoded microRNAs in oncogenesis. Retrovirology 2008. PMID: 18194563
Spillmann FJ, Beck-Engeser G, Wabl M. Differentiation and Ig-allele switch in cell line WEHI-231. Journal of immunology (Baltimore, Md. : 1950) 2007. PMID: 17982026
Schreiber K, Cannon RE, Karrison T, Beck-Engeser G, Huo D, Tennant RW, Jensen H, Kast WM, Krausz T, Meredith SC, Chen L, Schreiber H. Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors. Oncogene 2004. PMID: 15077191
Siegel CT, Schreiber K, Meredith SC, Beck-Engeser GB, Lancki DW, Lazarski CA, Fu YX, Rowley DA, Schreiber H. Enhanced growth of primary tumors in cancer-prone mice after immunization against the mutant region of an inherited oncoprotein. The Journal of experimental medicine 2000. PMID: 10839809
Donohoe ME, Beck-Engeser GB, Lonberg N, Karasuyama H, Riley RL, Jäck HM, Blomberg BB. Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype. Journal of immunology (Baltimore, Md. : 1950) 2000. PMID: 10799888
Kline GH, Hartwell L, Beck-Engeser GB, Keyna U, Zaharevitz S, Klinman NR, Jäck HM. Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional mu heavy chains. Journal of immunology (Baltimore, Md. : 1950) 1998. PMID: 9712022
Keyna U, Beck-Engeser GB, Jongstra J, Applequist SE, Jäck HM. Surrogate light chain-dependent selection of Ig heavy chain V regions. Journal of immunology (Baltimore, Md. : 1950) 1995. PMID: 7499835
Applequist SE, Keyna U, Calvin MR, Beck-Engeser GB, Raman C, Jäck HM. Sequence of the rabbit glyceraldehyde-3-phosphate dehydrogenase-encoding cDNA. Gene 1995. PMID: 7590291
Keyna U, Applequist SE, Jongstra J, Beck-Engeser GB, Jäck HM. Ig mu heavy chains with VH81X variable regions do not associate with lambda 5. Annals of the New York Academy of Sciences 1995. PMID: 7486553
Bornemann KD, Brewer JW, Beck-Engeser GB, Corley RB, Haas IG, Jäck HM. Roles of heavy and light chains in IgM polymerization. Proceedings of the National Academy of Sciences of the United States of America 1995. PMID: 7761423
Jäck HM, Beck-Engeser G, Sloan B, Wong ML, Wabl M. A different sort of Mott cell. Proceedings of the National Academy of Sciences of the United States of America 1992. PMID: 1465384
Jäck HM, Beck-Engeser G, Lee G, Wofsy D, Wabl M. Tumorigenesis mediated by an antigen receptor. Proceedings of the National Academy of Sciences of the United States of America 1992. PMID: 1528851
Heberlein C, Kawai M, Franz MJ, Beck-Engeser G, Daniel CP, Ostertag W, Stocking C. Retrotransposons as mutagens in the induction of growth autonomy in hematopoietic cells. Oncogene 1990. PMID: 2178239
Wabl M, Jäck HM, Meyer J, Beck-Engeser G, von Borstel RC, Steinberg CM. Measurements of mutation rates in B lymphocytes. Immunological reviews 1987. PMID: 3298012
Beck-Engeser G, Jäck HM, Wabl M. Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitro. Proceedings of the National Academy of Sciences of the United States of America 1987. PMID: 3103122
Wabl M, Meyer J, Beck-Engeser G, Tenkhoff M, Burrows PD. Critical test of a sister chromatid exchange model for the immunoglobulin heavy-chain class switch. Nature 1985. PMID: 3919304
Wabl MR, Beck-Engeser GB, Burrows PD. Allelic inclusion in the pre-B-cell line 18-81. Proceedings of the National Academy of Sciences of the United States of America 1984. PMID: 6322175
Burrows PD, Beck-Engeser GB, Wabl MR. Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement. Nature 1983. PMID: 6417542