Gabriele Beck-Engeser

Specialist

Gabriele Beck-Engeser (she/her/hers) grew up in Germany and attended the Medical Technical College in Esslingen/Germany for her undergraduate degree in Clinical Biology. During undergrad Gabriele became very interested in Immunology and following graduation she joined the laboratory of Dr. Matthias Wabl at the Max Planck Institute Tübingen/Germany working on the mechanism of immunoglobulin heavy-chain class switch.

Since starting her career in Tübingen, Gabriele moved to Hamburg and worked with Dr.Wolfram Ostertag at the Heinrich Pette Institute, University of Hamburg, Germany. Gabriele was involved in the regulation of hematopoietic cell proliferation and in the construction and testing of retroviral vectors for gene transfer into hematopoietic stem and precursor cells.
After Hamburg, Gabriele joined the laboratory of Dr. Hans-Martin Jäck at Loyola University Chicago Medical Center, USA. Gabriele helped Dr. Jäck to establish his laboratory and to start a new project dealing with the mechanisms of early B cell development. This gave her the opportunity to expand her abilities not only to work independently on her own projects, but also to teach graduate students and furthermore to organize the daily operation of Dr.Jäck's laboratory, which included supervising lab technicians, budget management and ordering of supplies.
After Dr. Jäck moved back to Germany Gabriele held a senior research specialist position in the tumor immunology laboratory of Dr. Hans Schreiber at the University of Chicago. Here she was involved in designing inducible vectors applying the cre-lox system and studied the synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors.

In 2006 Gabriele joined again the laboratory of Dr. Matthias Wabl. This time at the University of California, San Francisco (UCSF) studying B lymphocyte differentiation and the mutations that result in lymphomas and later the cause of systemic lupus erythematosus. In her day-to-day work, Gabriele planned and carried out most of the experiments, has been in charge of the mouse colony, oversaw the breeding and typing of the various strains of mice and served as lab manager.
In 2017 Gabriele joined the laboratory of Dr. Peter Hunt in the Department of Medicine, Division of Experimental Medicine, at UCSF. Gabriele performs assays on human cells and tissues including isolation and flow cytometry-based phenotyping of peripheral blood mononuclear cells, cell culture with stimulation and intracellular cytokine staining, cell proliferation assays, as well as ELISA-based plasma assays.

Gabriele co-authored 30 publications.

When not in the laboratory, Gabriele supports several outreach programs for homeless people in San Francisco, listens to Jazz and Blues music and is an avid reader.
Education
2019 - Diversity, Equity, and Inclusion Champion Training, University of California
11/2019 - Diversity, Equity, and Inclusion Champion Training, University of California
Publications
  1. Schnittman SR, Deitchman AN, Beck-Engeser G, Ahn H, York VA, Hartig H, Hecht FM, Martin JN, Deeks SG, Aweeka FT, Hunt PW. Abnormal Levels of Some Biomarkers of Immune Activation Despite Very Early Treatment of Human Immunodeficiency Virus. 2021. PMID: 32915986


  2. Böttinger P, Schreiber K, Hyjek E, Krausz T, Spiotto MT, Steiner M, Idel C, Booras H, Beck-Engeser G, Riederer J, Willimsky G, Wolf SP, Karrison T, Jensen E, Weichselbaum RR, Nakamura Y, Yew PY, Lambert PF, Kurita T, Kiyotani K, Leisegang M, Schreiber H. Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens. 2020. PMID: 32221533


  3. Beck-Engeser GB, Ahrends T, Knittel G, Wabl R, Metzner M, Eilat D, Wabl M. Infectivity and insertional mutagenesis of endogenous retrovirus in autoimmune NZB and B/W mice. 2015. PMID: 26315139


  4. Beck-Engeser GB, Winkelmann R, Wheeler ML, Shansab M, Yu P, Wünsche S, Walchhütter A, Metzner M, Vettermann C, Eilat D, DeFranco A, Jäck HM, Wabl M. APOBEC3 enzymes restrict marginal zone B cells. 2015. PMID: 25501566


  5. Knittel G, Metzner M, Beck-Engeser G, Kan A, Ahrends T, Eilat D, Huppi K, Wabl M. Insertional hypermutation in mineral oil-induced plasmacytomas. 2014. PMID: 24975032


  6. Beck-Engeser GB, Eilat D, Wabl M. An autoimmune disease prevented by anti-retroviral drugs. 2011. PMID: 22067273


  7. Lum AM, Wang BB, Beck-Engeser GB, Li L, Channa N, Wabl M. Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer. 2010. PMID: 20149256


  8. Beck-Engeser GB, Eilat D, Harrer T, Jäck HM, Wabl M. Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir. 2009. PMID: 19923437


  9. Schaller CE, Wang CL, Beck-Engeser G, Goss L, Scott HS, Anderson MS, Wabl M. Expression of Aire and the early wave of apoptosis in spermatogenesis. 2008. PMID: 18209027


  10. Beck-Engeser GB, Lum AM, Huppi K, Caplen NJ, Wang BB, Wabl M. Pvt1-encoded microRNAs in oncogenesis. 2008. PMID: 18194563


  11. Spillmann FJ, Beck-Engeser G, Wabl M. Differentiation and Ig-allele switch in cell line WEHI-231. 2007. PMID: 17982026


  12. Schreiber K, Cannon RE, Karrison T, Beck-Engeser G, Huo D, Tennant RW, Jensen H, Kast WM, Krausz T, Meredith SC, Chen L, Schreiber H. Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors. 2004. PMID: 15077191


  13. Beck-Engeser GB, Monach PA, Mumberg D, Yang F, Wanderling S, Schreiber K, Espinosa R, Le Beau MM, Meredith SC, Schreiber H. Point mutation in essential genes with loss or mutation of the second allele: relevance to the retention of tumor-specific antigens. 2001. PMID: 11489948


  14. Siegel CT, Schreiber K, Meredith SC, Beck-Engeser GB, Lancki DW, Lazarski CA, Fu YX, Rowley DA, Schreiber H. Enhanced growth of primary tumors in cancer-prone mice after immunization against the mutant region of an inherited oncoprotein. 2000. PMID: 10839809


  15. Donohoe ME, Beck-Engeser GB, Lonberg N, Karasuyama H, Riley RL, Jäck HM, Blomberg BB. Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype. 2000. PMID: 10799888


  16. Kline GH, Hartwell L, Beck-Engeser GB, Keyna U, Zaharevitz S, Klinman NR, Jäck HM. Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional mu heavy chains. 1998. PMID: 9712022


  17. Keyna U, Beck-Engeser GB, Jongstra J, Applequist SE, Jäck HM. Surrogate light chain-dependent selection of Ig heavy chain V regions. 1995. PMID: 7499835


  18. Applequist SE, Keyna U, Calvin MR, Beck-Engeser GB, Raman C, Jäck HM. Sequence of the rabbit glyceraldehyde-3-phosphate dehydrogenase-encoding cDNA. 1995. PMID: 7590291


  19. Keyna U, Applequist SE, Jongstra J, Beck-Engeser GB, Jäck HM. Ig mu heavy chains with VH81X variable regions do not associate with lambda 5. 1995. PMID: 7486553


  20. Bornemann KD, Brewer JW, Beck-Engeser GB, Corley RB, Haas IG, Jäck HM. Roles of heavy and light chains in IgM polymerization. 1995. PMID: 7761423


  21. Wabl MR, Beck-Engeser GB, Burrows PD. Allelic inclusion in the pre-B-cell line 18-81. 1984. PMID: 6322175