Since starting her career in Tübingen, Gabriele moved to Hamburg and worked with Dr.Wolfram Ostertag at the Heinrich Pette Institute, University of Hamburg, Germany. Gabriele was involved in the regulation of hematopoietic cell proliferation and in the construction and testing of retroviral vectors for gene transfer into hematopoietic stem and precursor cells.
After Hamburg, Gabriele joined the laboratory of Dr. Hans-Martin Jäck at Loyola University Chicago Medical Center, USA. Gabriele helped Dr. Jäck to establish his laboratory and to start a new project dealing with the mechanisms of early B cell development. This gave her the opportunity to expand her abilities not only to work independently on her own projects, but also to teach graduate students and furthermore to organize the daily operation of Dr.Jäck's laboratory, which included supervising lab technicians, budget management and ordering of supplies.
After Dr. Jäck moved back to Germany Gabriele held a senior research specialist position in the tumor immunology laboratory of Dr. Hans Schreiber at the University of Chicago. Here she was involved in designing inducible vectors applying the cre-lox system and studied the synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors.
In 2006 Gabriele joined again the laboratory of Dr. Matthias Wabl. This time at the University of California, San Francisco (UCSF) studying B lymphocyte differentiation and the mutations that result in lymphomas and later the cause of systemic lupus erythematosus. In her day-to-day work, Gabriele planned and carried out most of the experiments, has been in charge of the mouse colony, oversaw the breeding and typing of the various strains of mice and served as lab manager.
In 2017 Gabriele joined the laboratory of Dr. Peter Hunt in the Department of Medicine, Division of Experimental Medicine, at UCSF. Gabriele performs assays on human cells and tissues including isolation and flow cytometry-based phenotyping of peripheral blood mononuclear cells, cell culture with stimulation and intracellular cytokine staining, cell proliferation assays, as well as ELISA-based plasma assays.
Gabriele co-authored 30 publications.
When not in the laboratory, Gabriele supports several outreach programs for homeless people in San Francisco, listens to Jazz and Blues music and is an avid reader.
Schnittman SR, Deitchman AN, Beck-Engeser G, Ahn H, York VA, Hartig H, Hecht FM, Martin JN, Deeks SG, Aweeka FT, Hunt PW. Abnormal Levels of Some Biomarkers of Immune Activation Despite Very Early Treatment of Human Immunodeficiency Virus. 2021. PMID: 32915986
Böttinger P, Schreiber K, Hyjek E, Krausz T, Spiotto MT, Steiner M, Idel C, Booras H, Beck-Engeser G, Riederer J, Willimsky G, Wolf SP, Karrison T, Jensen E, Weichselbaum RR, Nakamura Y, Yew PY, Lambert PF, Kurita T, Kiyotani K, Leisegang M, Schreiber H. Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens. 2020. PMID: 32221533
Beck-Engeser GB, Ahrends T, Knittel G, Wabl R, Metzner M, Eilat D, Wabl M. Infectivity and insertional mutagenesis of endogenous retrovirus in autoimmune NZB and B/W mice. 2015. PMID: 26315139
Beck-Engeser GB, Winkelmann R, Wheeler ML, Shansab M, Yu P, Wünsche S, Walchhütter A, Metzner M, Vettermann C, Eilat D, DeFranco A, Jäck HM, Wabl M. APOBEC3 enzymes restrict marginal zone B cells. 2015. PMID: 25501566
Knittel G, Metzner M, Beck-Engeser G, Kan A, Ahrends T, Eilat D, Huppi K, Wabl M. Insertional hypermutation in mineral oil-induced plasmacytomas. 2014. PMID: 24975032
Beck-Engeser GB, Eilat D, Wabl M. An autoimmune disease prevented by anti-retroviral drugs. 2011. PMID: 22067273
Lum AM, Wang BB, Beck-Engeser GB, Li L, Channa N, Wabl M. Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer. 2010. PMID: 20149256
Beck-Engeser GB, Eilat D, Harrer T, Jäck HM, Wabl M. Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir. 2009. PMID: 19923437
Schaller CE, Wang CL, Beck-Engeser G, Goss L, Scott HS, Anderson MS, Wabl M. Expression of Aire and the early wave of apoptosis in spermatogenesis. 2008. PMID: 18209027
Beck-Engeser GB, Lum AM, Huppi K, Caplen NJ, Wang BB, Wabl M. Pvt1-encoded microRNAs in oncogenesis. 2008. PMID: 18194563
Spillmann FJ, Beck-Engeser G, Wabl M. Differentiation and Ig-allele switch in cell line WEHI-231. 2007. PMID: 17982026
Schreiber K, Cannon RE, Karrison T, Beck-Engeser G, Huo D, Tennant RW, Jensen H, Kast WM, Krausz T, Meredith SC, Chen L, Schreiber H. Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors. 2004. PMID: 15077191
Beck-Engeser GB, Monach PA, Mumberg D, Yang F, Wanderling S, Schreiber K, Espinosa R, Le Beau MM, Meredith SC, Schreiber H. Point mutation in essential genes with loss or mutation of the second allele: relevance to the retention of tumor-specific antigens. 2001. PMID: 11489948
Siegel CT, Schreiber K, Meredith SC, Beck-Engeser GB, Lancki DW, Lazarski CA, Fu YX, Rowley DA, Schreiber H. Enhanced growth of primary tumors in cancer-prone mice after immunization against the mutant region of an inherited oncoprotein. 2000. PMID: 10839809
Donohoe ME, Beck-Engeser GB, Lonberg N, Karasuyama H, Riley RL, Jäck HM, Blomberg BB. Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype. 2000. PMID: 10799888
Kline GH, Hartwell L, Beck-Engeser GB, Keyna U, Zaharevitz S, Klinman NR, Jäck HM. Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional mu heavy chains. 1998. PMID: 9712022
Keyna U, Beck-Engeser GB, Jongstra J, Applequist SE, Jäck HM. Surrogate light chain-dependent selection of Ig heavy chain V regions. 1995. PMID: 7499835
Applequist SE, Keyna U, Calvin MR, Beck-Engeser GB, Raman C, Jäck HM. Sequence of the rabbit glyceraldehyde-3-phosphate dehydrogenase-encoding cDNA. 1995. PMID: 7590291
Keyna U, Applequist SE, Jongstra J, Beck-Engeser GB, Jäck HM. Ig mu heavy chains with VH81X variable regions do not associate with lambda 5. 1995. PMID: 7486553
Bornemann KD, Brewer JW, Beck-Engeser GB, Corley RB, Haas IG, Jäck HM. Roles of heavy and light chains in IgM polymerization. 1995. PMID: 7761423
Wabl MR, Beck-Engeser GB, Burrows PD. Allelic inclusion in the pre-B-cell line 18-81. 1984. PMID: 6322175
Burrows PD, Beck-Engeser GB, Wabl MR. Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement. 1983. PMID: 6417542