Joseph (Mike) Mccune, MD, PhD

Education
Post-Doc Fellow/Scholar, 1988 - Pathology, Stanford University Medical College
Clinical Fellowship, 1986 - Infectious Disease, University of California, San Francisco
Residency, 1984 - Internal Medicine, University of California, San Francisco
M.D., 1982 - Medicine, Cornell University Medical College
Ph.D., 1981 - Cell Biology/Immunology, The Rockefeller University
A.B., 1975 - Biochemistry, Harvard College
Websites
Publications

  1. Olaghere J, Williams DA, Farrar J, Büning H, Calhoun C, Ho T, Inamdar MS, Liu D, Makani J, Nyarko K, Ruiz S, Tisdale J, McCune JM, Boadi E. Scientific Advancements in Gene Therapies: Opportunities for Global Regulatory Convergence. Biomedicines 2025. PMID: 40149734


  2. Lewin SR, Bansbach C, Kemps D, Mathae L, Das KT, McCune JM, Deeks SG, Ndung'u T, HIV Cure Gene Therapy Target Product Profile Working Group. Target product profile for cell-based and gene-based therapies to achieve a cure for HIV. The lancet. HIV 2025. PMID: 39761679


  3. Bukini D, Makani J, McCune J, Lee D, Bansbach C, De Vita S, Kemps D, Amin E, Spector J, Tisdale J. Consensus-driven target product profiles for curative sickle cell disease gene therapies. Molecular therapy. Methods & clinical development 2024. PMID: 39104574


  4. Doxzen KW, Adair JE, Fonseca Bazzo YM, Bukini D, Cornetta K, Dalal V, Guerino-Cunha RL, Hongeng S, Jotwani G, Kityo-Mutuluuza C, Lakshmanan K, Mahlangu J, Makani J, Mathews V, Ozelo MC, Rangarajan S, Scholefield J, Batista Silva Júnior J, McCune JM. The translational gap for gene therapies in low- and middle-income countries. Science translational medicine 2024. PMID: 38718130


  5. McCune JM, Kiem HP. Extending Gene Medicines to All in Need. The New England journal of medicine 2024. PMID: 38657269


  6. Harper J, Betts MR, Lichterfeld M, Müller-Trutwin M, Margolis D, Bar KJ, Li JZ, McCune JM, Lewin SR, Kulpa D, Ávila-Ríos S, Diallo DD, Lederman MM, Paiardini M. Erratum to: Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner? Pathogens & immunity 2024. PMID: 38505662


  7. Harper J, Betts MR, Lichterfeld M, Müller-Trutwin M, Margolis D, Bar KJ, Li JZ, McCune JM, Lewin SR, Kulpa D, Diallo DD, Lederman MM, Paiardini M. Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner? Pathogens & immunity 2024. PMID: 38455668


  8. Raizes E, Blandford J, McCune JM, Dybul M. The promise of a "cure" for HIV: implications for the future of PEPFAR-supported HIV programmes. Journal of the International AIDS Society 2024. PMID: 38193636


  9. Reeves DB, Bacchus-Souffan C, Fitch M, Abdel-Mohsen M, Hoh R, Ahn H, Stone M, Hecht F, Martin J, Deeks SG, Hellerstein MK, McCune JM, Schiffer JT, Hunt PW. Estimating the contribution of CD4 T cell subset proliferation and differentiation to HIV persistence. Nature communications 2023. PMID: 37783718


  10. Galy A, Berkhout B, Breckpot K, Pichon C, Bloom K, Kiem HP, Mühlebach MD, McCune JM. Recent Advances Using Genetic Therapies Against Infectious Diseases and for Vaccination. Human gene therapy 2023. PMID: 37639360


  12. Swainson LA, Sharma AA, Ghneim K, Ribeiro SP, Wilkinson P, Dunham RM, Albright RG, Wong S, Estes JD, Piatak M, Deeks SG, Hunt PW, Sekaly RP, McCune JM. IFNα-blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health. TO REMOVE 2022. PMID: 35104248


  13. Morcilla V, Bacchus-Souffan C, Fisher K, Horsburgh BA, Hiener B, Wang XQ, Schlub TE, Fitch M, Hoh R, Hecht FM, Martin JN, Deeks SG, Hellerstein MK, McCune JM, Hunt PW, Palmer S. HIV-1 Genomes Are Enriched in Memory CD4+ T-Cells with Short Half-Lives. mBio 2021. PMID: 34544282


  14. McCune JM, Stevenson SC, Doehle BP, Trenor CC, Turner EH, Spector JM. Collaborative science to advance gene therapies in resource-limited parts of the world. Molecular therapy : the journal of the American Society of Gene Therapy 2021. PMID: 34464598


  15. Rutishauser RL, Deguit CDT, Hiatt J, Blaeschke F, Roth TL, Wang L, Raymond KA, Starke CE, Mudd JC, Chen W, Smullin C, Matus-Nicodemos R, Hoh R, Krone M, Hecht FM, Pilcher CD, Martin JN, Koup RA, Douek DC, Brenchley JM, Sékaly RP, Pillai SK, Marson A, Deeks SG, McCune JM, Hunt PW. TCF-1 regulates HIV-specific CD8+ T cell expansion capacity. JCI insight 2021. PMID: 33351785


  16. Bacchus-Souffan C, Fitch M, Symons J, Abdel-Mohsen M, Reeves DB, Hoh R, Stone M, Hiatt J, Kim P, Chopra A, Ahn H, York VA, Cameron DL, Hecht FM, Martin JN, Yukl SA, Mallal S, Cameron PU, Deeks SG, Schiffer JT, Lewin SR, Hellerstein MK, McCune JM, Hunt PW. Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART. PLoS pathogens 2021. PMID: 33465157


  17. Bunis DG, Bronevetsky Y, Krow-Lucal E, Bhakta NR, Kim CC, Nerella S, Jones N, Mendoza VF, Bryson YJ, Gern JE, Rutishauser RL, Ye CJ, Sirota M, McCune JM, Burt TD. Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells. Cell reports 2021. PMID: 33406429


  18. Ahmed R, Miners KL, Lahoz-Beneytez J, Jones RE, Roger L, Baboonian C, Zhang Y, Wang ECY, Hellerstein MK, McCune JM, Baird DM, Price DA, Macallan DC, Asquith B, Ladell K. CD57+ Memory T Cells Proliferate In Vivo. Cell reports 2020. PMID: 33326780


  19. Lewin SR, Attoye T, Bansbach C, Doehle B, Dubé K, Dybul M, SenGupta D, Jiang A, Johnston R, Lamplough R, McCune JM, Nabel GJ, Ndung'u T, Pottage J, Ripin D, Rooney JF, Sikazwe I, Nsubuga M, Warren M, Deeks SG, Sunnylands 2019 Working Group. Multi-stakeholder consensus on a target product profile for an HIV cure. The lancet. HIV 2020. PMID: 33271125


  20. Dybul M, Attoye T, Baptiste S, Cherutich P, Dabis F, Deeks SG, Dieffenbach C, Doehle B, Goodenow MM, Jiang A, Kemps D, Lewin SR, Lumpkin MM, Mathae L, McCune JM, Ndung'u T, Nsubuga M, Peay HL, Pottage J, Warren M, Sikazwe I, Sunnylands 2019 Working Group. The case for an HIV cure and how to get there. The lancet. HIV 2020. PMID: 33271124


  21. McCune JM, Turner EH, Jiang A, Doehle B. Bringing Gene Therapies for HIV Disease to Resource-Limited Parts of the World. Human gene therapy 2020. PMID: 32998595


  22. Johnson SR, Brinks R, Costenbader KH, Daikh D, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstrøm K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Tani C, Tedeschi SK, Touma Z, Schmajuk G, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirják L, Doria A, Graninger WB, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kumánovics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, Rúa-Figueroa Í, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, Dörner T, Aringer M. Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities. Annals of the rheumatic diseases 2020. PMID: 32816709


  23. Cham LB, Torrez Dulgeroff LB, Tal MC, Adomati T, Li F, Bhat H, Huang A, Lang PA, Moreno ME, Rivera JM, Galkina SA, Kosikova G, Stoddart CA, McCune JM, Myers LM, Weissman IL, Lang KS, Hasenkrug KJ. Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection. Cell reports 2020. PMID: 32294445


  24. Ndung'u T, McCune JM, Deeks SG. Why and where an HIV cure is needed and how it might be achieved. Nature 2019. PMID: 31853080


  26. Deguit CDT, Hough M, Hoh R, Krone M, Pilcher CD, Martin JN, Deeks SG, McCune JM, Hunt PW, Rutishauser RL. Some Aspects of CD8+ T-Cell Exhaustion Are Associated With Altered T-Cell Mitochondrial Features and ROS Content in HIV Infection. Journal of acquired immune deficiency syndromes (1999) 2019. PMID: 31513075


  27. Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstrøm K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Tani C, Tedeschi SK, Touma Z, Schmajuk G, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirják L, Doria A, Graninger W, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kumánovics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, Rúa-Figueroa Fernández Í, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, Dörner T, Johnson SR. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. Arthritis & rheumatology (Hoboken, N.J.) 2019. PMID: 31385462


  28. Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstrøm K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Tani C, Tedeschi SK, Touma Z, Schmajuk G, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirják L, Doria A, Graninger W, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kumánovics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, Rúa-Figueroa Fernández Í, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, Dörner T, Johnson SR. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Annals of the rheumatic diseases 2019. PMID: 31383717


  29. Swainson LA, Ahn H, Pajanirassa P, Khetarpal V, Deleage C, Estes JD, Hunt PW, Munoz-Sanjuan I, McCune JM. Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post-Combination Antiretroviral Therapy CD4+ T Cell Counts and Body Weight. Journal of immunology (Baltimore, Md. : 1950) 2019. PMID: 31285277


  30. Vásquez JJ, Aguilar-Rodriguez BL, Rodriguez L, Hogan LE, Somsouk M, McCune JM, Deeks SG, Laszik ZG, Hunt PW, Henrich TJ. CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals. Pathogens & immunity 2019. PMID: 31139759


  31. Peluso MJ, Deeks SG, McCune JM. HIV "cure": A shot in the arm? EBioMedicine 2019. PMID: 30982768


  32. Hanscombe KB, Morris DL, Noble JA, Dilthey AT, Tombleson P, Kaufman KM, Comeau M, Langefeld CD, Alarcon-Riquelme ME, Gaffney PM, Jacob CO, Sivils KL, Tsao BP, Alarcon GS, Brown EE, Croker J, Edberg J, Gilkeson G, James JA, Kamen DL, Kelly JA, McCune J, Merrill JT, Petri M, Ramsey-Goldman R, Reveille JD, Salmon JE, Scofield H, Utset T, Wallace DJ, Weisman MH, Kimberly RP, Harley JB, Lewis CM, Criswell LA, Vyse TJ. Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans. Human molecular genetics 2018. PMID: 30085094


  33. Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM. A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS pathogens 2018. PMID: 29505600


  34. Vasquez JJ, Hussien R, Aguilar-Rodriguez B, Junger H, Dobi D, Henrich TJ, Thanh C, Gibson E, Hogan LE, McCune J, Hunt PW, Stoddart CA, Laszik ZG. Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization: Methods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2018. PMID: 29462571


  35. Anzinger JJ, Butterfield TR, Gouillou M, McCune JM, Crowe SM, Palmer CS. Glut1 Expression Level on Inflammatory Monocytes is Associated With Markers of Cardiovascular Disease Risk in HIV-Infected Individuals. Journal of acquired immune deficiency syndromes (1999) 2018. PMID: 28961681


  36. Méndez-Lagares G, Lu D, Chen C, Terrault N, Segal MR, Khalili M, Monto A, Shen H, Manos MM, Lanier LL, Ryan JC, McCune JM, Hartigan-O'Connor DJ. Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success. Volume 200 of Issue 3. Journal of immunology (Baltimore, Md. : 1950) 2017. PMID: 29263212


  37. Henrich TJ, Hatano H, Bacon O, Hogan LE, Rutishauser R, Hill A, Kearney MF, Anderson EM, Buchbinder SP, Cohen SE, Abdel-Mohsen M, Pohlmeyer CW, Fromentin R, Hoh R, Liu AY, McCune JM, Spindler J, Metcalf-Pate K, Hobbs KS, Thanh C, Gibson EA, Kuritzkes DR, Siliciano RF, Price RW, Richman DD, Chomont N, Siliciano JD, Mellors JW, Yukl SA, Blankson JN, Liegler T, Deeks SG. HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study. PLoS medicine 2017. PMID: 29112956


  38. Méndez-Lagares G, Lu D, Merriam D, Baker CA, Villinger F, Van Rompay KKA, McCune JM, Hartigan-O'Connor DJ. IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8+ T Cell Responses in Acute Simian Immunodeficiency Virus Infection. AIDS research and human retroviruses 2017. PMID: 29140110


  39. Palmer CS, Duette GA, Wagner MCE, Henstridge DC, Saleh S, Pereira C, Zhou J, Simar D, Lewin SR, Ostrowski M, McCune JM, Crowe SM. Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection. FEBS letters 2017. PMID: 28892135


  40. Estes JD, Kityo C, Ssali F, Swainson L, Makamdop KN, Del Prete GQ, Deeks SG, Luciw PA, Chipman JG, Beilman GJ, Hoskuldsson T, Khoruts A, Anderson J, Deleage C, Jasurda J, Schmidt TE, Hafertepe M, Callisto SP, Pearson H, Reimann T, Schuster J, Schoephoerster J, Southern P, Perkey K, Shang L, Wietgrefe SW, Fletcher CV, Lifson JD, Douek DC, McCune JM, Haase AT, Schacker TW. Defining total-body AIDS-virus burden with implications for curative strategies. Nature medicine 2017. PMID: 28967921


  41. Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR. Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells. Cell reports 2017. PMID: 28746881


  42. Langefeld CD, Ainsworth HC, Cunninghame Graham DS, Kelly JA, Comeau ME, Marion MC, Howard TD, Ramos PS, Croker JA, Morris DL, Sandling JK, Almlöf JC, Acevedo-Vásquez EM, Alarcón GS, Babini AM, Baca V, Bengtsson AA, Berbotto GA, Bijl M, Brown EE, Brunner HI, Cardiel MH, Catoggio L, Cervera R, Cucho-Venegas JM, Dahlqvist SR, D'Alfonso S, Da Silva BM, de la Rúa Figueroa I, Doria A, Edberg JC, Endreffy E, Esquivel-Valerio JA, Fortin PR, Freedman BI, Frostegård J, García MA, de la Torre IG, Gilkeson GS, Gladman DD, Gunnarsson I, Guthridge JM, Huggins JL, James JA, Kallenberg CGM, Kamen DL, Karp DR, Kaufman KM, Kottyan LC, Kovács L, Laustrup H, Lauwerys BR, Li QZ, Maradiaga-Ceceña MA, Martín J, McCune JM, McWilliams DR, Merrill JT, Miranda P, Moctezuma JF, Nath SK, Niewold TB, Orozco L, Ortego-Centeno N, Petri M, Pineau CA, Pons-Estel BA, Pope J, Raj P, Ramsey-Goldman R, Reveille JD, Russell LP, Sabio JM, Aguilar-Salinas CA, Scherbarth HR, Scorza R, Seldin MF, Sjöwall C, Svenungsson E, Thompson SD, Toloza SMA, Truedsson L, Tusié-Luna T, Vasconcelos C, Vilá LM, Wallace DJ, Weisman MH, Wither JE, Bhangale T, Oksenberg JR, Rioux JD, Gregersen PK, Syvänen AC, Rönnblom L, Criswell LA, Jacob CO, Sivils KL, Tsao BP, Schanberg LE, Behrens TW, Silverman ED, Alarcón-Riquelme ME, Kimberly RP, Harley JB, Wakeland EK, Graham RR, Gaffney PM, Vyse TJ. Transancestral mapping and genetic load in systemic lupus erythematosus. Nature communications 2017. PMID: 28714469


  43. Vujkovic-Cvijin I, Rutishauser RL, Pao M, Hunt PW, Lynch SV, McCune JM, Somsouk M. Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals. Gut microbes 2017. PMID: 28541799


  44. Rutishauser RL, Hartogensis W, Deguit CD, Krone M, Hoh R, Hecht FM, Pilcher CD, Bacchetti P, Deeks SG, Hunt PW, McCune JM. Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8+ T Cell Exhaustion Marker Expression. AIDS research and human retroviruses 2017. PMID: 28335609


  45. Trang K, Raposo RA, Lowe MM, Krow-Lucal ER, Yonemoto W, Cabido VD, SenGupta D, McCune JM. Relative mRNA Expression Levels of Restriction Factors and Antiviral Genes in Fetal and Adult Human Monocytes and Monocyte-Derived Macrophages. Viral immunology 2017. PMID: 28151065


  46. Bronevetsky Y, Burt TD, McCune JM. Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-ß Signaling. Volume 197 of Issue 11. Journal of immunology (Baltimore, Md. : 1950) 2016. PMID: 27793996


  47. Shastri R, Shah G, Wang P, Cagnoli P, Schmidt-Wilcke T, McCune J, Harris R, Sundgren P. MR Diffusion Tractography to Identify and Characterize Microstructural White Matter Tract Changes in Systemic Lupus Erythematosus Patients. Academic radiology 2016. PMID: 27746120


  48. McCune JM. Henry Kunkel and the teaching of patient-oriented research. Clinical immunology (Orlando, Fla.) 2016. PMID: 27538773


  49. Palmer CS, Anzinger JJ, Butterfield TR, McCune JM, Crowe SM. A Simple Flow Cytometric Method to Measure Glucose Uptake and Glucose Transporter Expression for Monocyte Subpopulations in Whole Blood. Journal of visualized experiments : JoVE 2016. PMID: 27584036


  50. Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nature medicine 2016. PMID: 27400264


  51. Deleage C, Schuetz A, Alvord WG, Johnston L, Hao XP, Morcock DR, Rerknimitr R, Fletcher JL, Puttamaswin S, Phanuphak N, Dewar R, McCune JM, Sereti I, Robb M, Kim JH, Schacker TW, Hunt P, Lifson JD, Ananworanich J, Estes JD. Impact of early cART in the gut during acute HIV infection. Volume 1 of Issue 10. JCI insight 2016. PMID: 27446990


  52. Cunyat F, Rainho JN, West B, Swainson L, McCune JM, Stevenson M. Colony-Stimulating Factor 1 Receptor Antagonists Sensitize Human Immunodeficiency Virus Type 1-Infected Macrophages to TRAIL-Mediated Killing. Journal of virology 2016. PMID: 27122585


  53. Younes SA, Freeman ML, Mudd JC, Shive CL, Reynaldi A, Panigrahi S, Estes JD, Deleage C, Lucero C, Anderson J, Schacker TW, Davenport MP, McCune JM, Hunt PW, Lee SA, Serrano-Villar S, Debernardo RL, Jacobson JM, Canaday DH, Sekaly RP, Rodriguez B, Sieg SF, Lederman MM. IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection. Volume 126 of Issue 7. The Journal of clinical investigation 2016. PMID: 27322062


  54. Ramirez CM, Sinclair E, Epling L, Lee SA, Jain V, Hsue PY, Hatano H, Conn D, Hecht FM, Martin JN, McCune JM, Deeks SG, Hunt PW. Immunologic profiles distinguish aviremic HIV-infected adults. Volume 30 of Issue 10. AIDS (London, England) 2016. PMID: 26854811


  55. Heiden D, Saranchuk P, Keenan JD, Ford N, Lowinger A, Yen M, McCune J, Rao NA. Eye examination for early diagnosis of disseminated tuberculosis in patients with AIDS. The Lancet. Infectious diseases 2016. PMID: 26907735


  56. Lederman MM, Cannon PM, Currier JS, June CH, Kiem HP, Kuritzkes DR, Lewin SR, Margolis DM, McCune JM, Mellors JW, Schacker TW, Sekaly RP, Tebas P, Walker BD, Douek DC. A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"? Pathogens & immunity 2016. PMID: 27668293


  57. Deleage C, Wietgrefe SW, Del Prete G, Morcock DR, Hao XP, Piatak M, Bess J, Anderson JL, Perkey KE, Reilly C, McCune JM, Haase AT, Lifson JD, Schacker TW, Estes JD. Defining HIV and SIV Reservoirs in Lymphoid Tissues. Pathogens & immunity 2016. PMID: 27430032


  58. Vujkovic-Cvijin I, Swainson LA, Chu SN, Ortiz AM, Santee CA, Petriello A, Dunham RM, Fadrosh DW, Lin DL, Faruqi AA, Huang Y, Apetrei C, Pandrea I, Hecht FM, Pilcher CD, Klatt NR, Brenchley JM, Lynch SV, McCune JM. Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques. Volume 13 of Issue 8. Cell reports 2015. PMID: 26586432


  59. Ladell K, Hazenberg MD, Fitch M, Emson C, McEvoy-Hein Asgarian BK, Mold JE, Miller C, Busch R, Price DA, Hellerstein MK, McCune JM. Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1ß: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease. Journal of immunology (Baltimore, Md. : 1950) 2015. PMID: 26416271


  60. Ortiz AM, Klase ZA, DiNapoli SR, Vujkovic-Cvijin I, Carmack K, Perkins MR, Calantone N, Vinton CL, Riddick NE, Gallagher J, Klatt NR, McCune JM, Estes JD, Paiardini M, Brenchley JM. IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques. Mucosal immunology 2015. PMID: 26286233


  61. Baker CA, Swainson L, Lin DL, Wong S, Hartigan-O'Connor DJ, Lifson JD, Tarantal AF, McCune JM. Exposure to SIV in utero results in reduced viral loads and altered responsiveness to postnatal challenge. Science translational medicine 2015. PMID: 26268312


  62. PrabhuDas M, Bonney E, Caron K, Dey S, Erlebacher A, Fazleabas A, Fisher S, Golos T, Matzuk M, McCune JM, Mor G, Schulz L, Soares M, Spencer T, Strominger J, Way SS, Yoshinaga K. Immune mechanisms at the maternal-fetal interface: perspectives and challenges. Nature immunology 2015. PMID: 25789673


  63. Somsouk M, Estes JD, Deleage C, Dunham RM, Albright R, Inadomi JM, Martin JN, Deeks SG, McCune JM, Hunt PW. Gut epithelial barrier and systemic inflammation during chronic HIV infection. Volume 29 of Issue 1. AIDS (London, England) 2015. PMID: 25387317


  64. Moniuszko M, Liyanage NP, Doster MN, Parks RW, Grubczak K, Lipinska D, McKinnon K, Brown C, Hirsch V, Vaccari M, Gordon S, Pegu P, Fenizia C, Flisiak R, Grzeszczuk A, Dabrowska M, Robert-Guroff M, Silvestri G, Stevenson M, McCune J, Franchini G. Glucocorticoid treatment at moderate doses of SIVmac251-infected rhesus macaques decreases the frequency of circulating CD14+CD16++ monocytes but does not alter the tissue virus reservoir. AIDS research and human retroviruses 2015. PMID: 24432835


  65. Somsouk M, Dunham RM, Cohen M, Albright R, Abdel-Mohsen M, Liegler T, Lifson J, Piatak M, Gorelick R, Huang Y, Wu Y, Hsue PY, Martin JN, Deeks SG, McCune JM, Hunt PW. The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial. Volume 9 of Issue 12. PloS one 2014. PMID: 25545673


  66. Palmer CS, Anzinger JJ, Zhou J, Gouillou M, Landay A, Jaworowski A, McCune JM, Crowe SM. Glucose transporter 1-expressing proinflammatory monocytes are elevated in combination antiretroviral therapy-treated and untreated HIV+ subjects. Journal of immunology (Baltimore, Md. : 1950) 2014. PMID: 25367121


  67. Seu L, Ortiz GM, Burt TD, Deeks SG, Martin JN, McCune JM. Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4(+) T cell recovery after the initiation of antiretroviral therapy for HIV disease. Volume 11. AIDS research and therapy 2014. PMID: 25180041


  68. Cockerham LR, Jain V, Sinclair E, Glidden DV, Hartogenesis W, Hatano H, Hunt PW, Martin JN, Pilcher CD, Sekaly R, McCune JM, Hecht FM, Deeks SG. Programmed death-1 expression on CD4? and CD8? T cells in treated and untreated HIV disease. Volume 28 of Issue 12. AIDS (London, England) 2014. PMID: 24871455


  69. Krow-Lucal ER, McCune JM. Distinct functional programs in fetal T and myeloid lineages. Frontiers in immunology 2014. PMID: 25071775


  70. Batchelder CA, Duru N, Lee CI, Baker CA, Swainson L, Mccune JM, Tarantal AF. Myeloid-lymphoid ontogeny in the rhesus monkey (Macaca mulatta). Anatomical record (Hoboken, N.J. : 2007) 2014. PMID: 24867874


  71. Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. Volume 10 of Issue 5. PLoS pathogens 2014. PMID: 24831517


  72. Lee SA, Sinclair E, Jain V, Huang Y, Epling L, Van Natta M, Meinert CL, Martin JN, McCune JM, Deeks SG, Lederman MM, Hecht FM, Hunt PW. Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection. Volume 210 of Issue 3. The Journal of infectious diseases 2014. PMID: 24585893


  73. Byakwaga H, Boum Y, Huang Y, Muzoora C, Kembabazi A, Weiser SD, Bennett J, Cao H, Haberer JE, Deeks SG, Bangsberg DR, McCune JM, Martin JN, Hunt PW. The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy. Volume 210 of Issue 3. The Journal of infectious diseases 2014. PMID: 24585899


  74. Lee SA, Sinclair E, Hatano H, Hsue PY, Epling L, Hecht FM, Bangsberg DR, Martin JN, McCune JM, Deeks SG, Hunt PW. Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging. Volume 9 of Issue 2. PloS one 2014. PMID: 24586783


  75. Krow-Lucal ER, Kim CC, Burt TD, McCune JM. Distinct functional programming of human fetal and adult monocytes. Volume 123 of Issue 12. Blood 2014. PMID: 24518760


  76. Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger J, Sherr DH, Silverstone AE, Hahn ME, McCune JM. Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PloS one 2014. PMID: 24498387


  77. Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM. Discordance between peripheral and colonic markers of inflammation during suppressive ART. Volume 65 of Issue 2. Journal of acquired immune deficiency syndromes (1999) 2014. PMID: 24121758


  78. Palmer CS, Ostrowski M, Gouillou M, Tsai L, Yu D, Zhou J, Henstridge DC, Maisa A, Hearps AC, Lewin SR, Landay A, Jaworowski A, McCune JM, Crowe SM. Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection. AIDS (London, England) 2014. PMID: 24335483


  79. Emu B, Moretto WJ, Hoh R, Krone M, Martin JN, Nixon DF, Deeks SG, McCune JM. Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease. PloS one 2014. PMID: 24465619


  80. Bakkour S, Baker CA, Tarantal AF, Wen L, Busch MP, Lee TH, McCune JM. Analysis of maternal microchimerism in rhesus monkeys (Macaca mulatta) using real-time quantitative PCR amplification of MHC polymorphisms. Chimerism 2014. PMID: 24451553


  81. Seu L, Ortiz GM, Epling L, Sinclair E, Swainson LA, Bajpai UD, Huang Y, Deeks SG, Hunt PW, Martin JN, McCune JM. Higher CD27+CD8+ T cells percentages during suppressive antiretroviral therapy predict greater subsequent CD4+ T cell recovery in treated HIV infection. Volume 8 of Issue 12. PloS one 2013. PMID: 24391889


  82. Hartigan-O'Connor DJ, Lin D, Ryan JC, Shvachko VA, Cozen ML, Segal MR, Terrault NA, Lanier LL, Manos MM, McCune JM. Monocyte activation by interferon a is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection. The Journal of infectious diseases 2013. PMID: 24325966


  83. Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG. Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. Volume 9 of Issue 10. PLoS pathogens 2013. PMID: 24130489


  84. Hatano H, Strain MC, Scherzer R, Bacchetti P, Wentworth D, Hoh R, Martin JN, McCune JM, Neaton JD, Tracy RP, Hsue PY, Richman DD, Deeks SG. Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial. The Journal of infectious diseases 2013. PMID: 23975885


  85. Jain V, Hartogensis W, Bacchetti P, Hunt PW, Hatano H, Sinclair E, Epling L, Lee TH, Busch MP, McCune JM, Pilcher CD, Hecht FM, Deeks SG. Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size. Volume 208 of Issue 8. The Journal of infectious diseases 2013. PMID: 23852127


  86. Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM. Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Volume 5 of Issue 193. Science translational medicine 2013. PMID: 23843452


  87. Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. International immunology 2013. PMID: 23657000


  88. Broadhurst MJ, Ardeshir A, Kanwar B, Mirpuri J, Gundra UM, Leung JM, Wiens KE, Vujkovic-Cvijin I, Kim CC, Yarovinsky F, Lerche NW, McCune JM, Loke P. Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon. PLoS pathogens 2012. PMID: 23166490


  89. Hatano H, Jain V, Hunt PW, Lee TH, Sinclair E, Do TD, Hoh R, Martin JN, McCune JM, Hecht F, Busch MP, Deeks SG. Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells. Volume 208 of Issue 1. The Journal of infectious diseases 2012. PMID: 23089590


  90. Dunham RM, Gordon SN, Vaccari M, Piatak M, Huang Y, Deeks SG, Lifson J, Franchini G, McCune JM. Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase. AIDS research and human retroviruses 2012. PMID: 22924680


  91. Broadhurst MJ, Leung JM, Lim KC, Girgis NM, Gundra UM, Fallon PG, Premenko-Lanier M, McKerrow JH, McCune JM, Loke P. Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice. PLoS pathogens 2012. PMID: 22927819


  92. Bajpai UD, Swainson LA, Mold JE, Graf JD, Imboden JB, McCune JM. A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity. Volume 64 of Issue 8. Arthritis and rheumatism 2012. PMID: 22392608


  94. Deeks SG, Verdin E, McCune JM. Immunosenescence and HIV. Current opinion in immunology 2012. PMID: 22658763


  95. Hartigan-O'Connor DJ, Abel K, Van Rompay KK, Kanwar B, McCune JM. SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment. Science translational medicine 2012. PMID: 22649090


  96. Brown JN, Ortiz GM, Angel TE, Jacobs JM, Gritsenko M, Chan EY, Purdy DE, Murnane RD, Larsen K, Palermo RE, Shukla AK, Clauss TR, Katze MG, McCune JM, Smith RD. Morphine produces immunosuppressive effects in nonhuman primates at the proteomic and cellular levels. Molecular & cellular proteomics : MCP 2012. PMID: 22580588


  97. Sacre K, Hunt PW, Hsue PY, Maidji E, Martin JN, Deeks SG, Autran B, McCune JM. A role for cytomegalovirus-specific CD4+CX3CR1+ T cells and cytomegalovirus-induced T-cell immunopathology in HIV-associated atherosclerosis. Volume 26 of Issue 7. AIDS (London, England) 2012. PMID: 22313962


  98. Baum PD, Young JJ, Schmidt D, Zhang Q, Hoh R, Busch M, Martin J, Deeks S, McCune JM. Blood T-cell receptor diversity decreases during the course of HIV infection, but the potential for a diverse repertoire persists. Blood 2012. PMID: 22371879


  99. Kiem HP, Jerome KR, Deeks SG, McCune JM. Hematopoietic-stem-cell-based gene therapy for HIV disease. Cell stem cell 2012. PMID: 22305563


  100. Mold JE, McCune JM. Immunological tolerance during fetal development: from mouse to man. Advances in immunology 2012. PMID: 22608256


  101. Baum PD, Sullam PM, Stoddart CA, McCune JM. Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase. Volume 25 of Issue 18. AIDS (London, England) 2011. PMID: 21941165


  102. Seu L, Burt TD, Witte JS, Martin JN, Deeks SG, McCune JM. Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans. Volume 13 of Issue 3. Genes and immunity 2011. PMID: 22048453


  103. Kitchen CM, Yeghiazarian L, Hoh R, McCune JM, Sinclair E, Martin JN, Deeks SG. Immune activation, CD4+ T cell counts, and viremia exhibit oscillatory patterns over time in patients with highly resistant HIV infection. Volume 6 of Issue 6. PloS one 2011. PMID: 21701594


  104. Bacchetti P, Deeks SG, McCune JM. Breaking free of sample size dogma to perform innovative translational research. Science translational medicine 2011. PMID: 21677197


  105. Hartigan-O'Connor DJ, Hirao LA, McCune JM, Dandekar S. Th17 cells and regulatory T cells in elite control over HIV and SIV. Current opinion in HIV and AIDS 2011. PMID: 21399494


  106. Hatano H, Hayes TL, Dahl V, Sinclair E, Lee TH, Hoh R, Lampiris H, Hunt PW, Palmer S, McCune JM, Martin JN, Busch MP, Shacklett BL, Deeks SG. A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response. Volume 203 of Issue 7. The Journal of infectious diseases 2011. PMID: 21402547


  108. Baum PD, Young JJ, McCune JM. Measurement of absolute T cell receptor rearrangement diversity. Journal of immunological methods 2011. PMID: 21385585


  109. Hunt PW, Landay AL, Sinclair E, Martinson JA, Hatano H, Emu B, Norris PJ, Busch MP, Martin JN, Brooks C, McCune JM, Deeks SG. A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers. Volume 6 of Issue 1. PloS one 2011. PMID: 21305005


  110. Hunt PW, Hatano H, Sinclair E, Lee TH, Busch MP, Martin JN, McCune JM, Deeks SG. HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllers. Volume 52 of Issue 5. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011. PMID: 21245154


  111. Babik JM, Cohan D, Monto A, Hartigan-O'Connor DJ, McCune JM. The human fetal immune response to hepatitis C virus exposure in utero. Volume 203 of Issue 2. The Journal of infectious diseases 2011. PMID: 21288819


  112. Favre D, Stoddart CA, Emu B, Hoh R, Martin JN, Hecht FM, Deeks SG, McCune JM. HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells. Volume 117 of Issue 7. Blood 2011. PMID: 21200021


  113. Mold JE, Venkatasubrahmanyam S, Burt TD, Michaëlsson J, Rivera JM, Galkina SA, Weinberg K, Stoddart CA, McCune JM. Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. Volume 330 of Issue 6011. Science (New York, N.Y.) 2010. PMID: 21164017


  114. Broadhurst MJ, Leung JM, Kashyap V, McCune JM, Mahadevan U, McKerrow JH, Loke P. IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient. Science translational medicine 2010. PMID: 21123809


  115. Baum PD, Young JJ, Zhang Q, Kasakow Z, McCune JM. Design, construction, and validation of a modular library of sequence diversity standards for polymerase chain reaction. Analytical biochemistry 2010. PMID: 21111699


  116. Burt TD, Seu L, Mold JE, Kappas A, McCune JM. Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin. Volume 185 of Issue 9. Journal of immunology (Baltimore, Md. : 1950) 2010. PMID: 20921523


  117. Lee TH, Chafets DM, Biggar RJ, McCune JM, Busch MP. The role of transplacental microtransfusions of maternal lymphocytes in in utero HIV transmission. Journal of acquired immune deficiency syndromes (1999) 2010. PMID: 20683195


  118. Deeks SG, McCune JM. Can HIV be cured with stem cell therapy? Nature biotechnology 2010. PMID: 20697404


  119. Favre D, Mold J, Hunt PW, Kanwar B, Loke P, Seu L, Barbour JD, Lowe MM, Jayawardene A, Aweeka F, Huang Y, Douek DC, Brenchley JM, Martin JN, Hecht FM, Deeks SG, McCune JM. Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Volume 2 of Issue 32. Science translational medicine 2010. PMID: 20484731


  120. Kanwar B, Favre D, McCune JM. Th17 and regulatory T cells: implications for AIDS pathogenesis. Current opinion in HIV and AIDS 2010. PMID: 20543593


  121. Swainson LA, Mold JE, Bajpai UD, McCune JM. Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1. Journal of immunology (Baltimore, Md. : 1950) 2010. PMID: 20190142


  122. Stoddart CA, Keir ME, McCune JM. IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo. Volume 6 of Issue 2. PLoS pathogens 2010. PMID: 20174557


  123. Loke P, Favre D, Hunt PW, Leung JM, Kanwar B, Martin JN, Deeks SG, McCune JM. Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers. Volume 115 of Issue 15. Blood 2010. PMID: 20160163


  124. Naeger DM, Martin JN, Sinclair E, Hunt PW, Bangsberg DR, Hecht F, Hsue P, McCune JM, Deeks SG. Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease. Volume 5 of Issue 1. PloS one 2010. PMID: 20126452


  125. Cheng LE, Kanwar B, Tcheurekdjian H, Grenert JP, Muskat M, Heyman MB, McCune JM, Wara DW. Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome. Volume 132 of Issue 1. Clinical immunology (Orlando, Fla.) 2009. PMID: 19375390


  126. Favre D, Lederer S, Kanwar B, Ma ZM, Proll S, Kasakow Z, Mold J, Swainson L, Barbour JD, Baskin CR, Palermo R, Pandrea I, Miller CJ, Katze MG, McCune JM. Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS pathogens 2009. PMID: 19214220


  127. Lederer S, Favre D, Walters KA, Proll S, Kanwar B, Kasakow Z, Baskin CR, Palermo R, McCune JM, Katze MG. Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization. PLoS pathogens 2009. PMID: 19214219


  128. Contreras X, Schweneker M, Chen CS, McCune JM, Deeks SG, Martin J, Peterlin BM. Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells. The Journal of biological chemistry 2009. PMID: 19136668


  129. Lozano Reina JM, Favre D, Kasakow Z, Mayau V, Nugeyre MT, Ka T, Faye A, Miller CJ, Scott-Algara D, McCune JM, Barré-Sinoussi F, Diop OM, Müller-Trutwin MC. Gag p27-specific B- and T-cell responses in Simian immunodeficiency virus SIVagm-infected African green monkeys. Journal of virology 2008. PMID: 19109377


  130. Mold JE, Michaëlsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, Lee TH, Nixon DF, McCune JM. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Volume 322 of Issue 5907. Science (New York, N.Y.) 2008. PMID: 19056990


  131. Jones RB, Ndhlovu LC, Barbour JD, Sheth PM, Jha AR, Long BR, Wong JC, Satkunarajah M, Schweneker M, Chapman JM, Gyenes G, Vali B, Hyrcza MD, Yue FY, Kovacs C, Sassi A, Loutfy M, Halpenny R, Persad D, Spotts G, Hecht FM, Chun TW, McCune JM, Kaul R, Rini JM, Nixon DF, Ostrowski MA. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. The Journal of experimental medicine 2008. PMID: 19001139


  132. Hatano H, Delwart EL, Norris PJ, Lee TH, Dunn-Williams J, Hunt PW, Hoh R, Stramer SL, Linnen JM, McCune JM, Martin JN, Busch MP, Deeks SG. Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy. Volume 83 of Issue 1. Journal of virology 2008. PMID: 18945778


  133. Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Volume 105 of Issue 25. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 18562290


  134. Ladell K, Hellerstein MK, Cesar D, Busch R, Boban D, McCune JM. Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression. Journal of immunology (Baltimore, Md. : 1950) 2008. PMID: 18523254


  135. Schweneker M, Favre D, Martin JN, Deeks SG, McCune JM. HIV-induced changes in T cell signaling pathways. Journal of immunology (Baltimore, Md. : 1950) 2008. PMID: 18453567


  136. Emu B, Sinclair E, Hatano H, Ferre A, Shacklett B, Martin JN, McCune JM, Deeks SG. HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control. Volume 82 of Issue 11. Journal of virology 2008. PMID: 18353945


  137. Napolitano LA, Schmidt D, Gotway MB, Ameli N, Filbert EL, Ng MM, Clor JL, Epling L, Sinclair E, Baum PD, Li K, Killian ML, Bacchetti P, McCune JM. Growth hormone enhances thymic function in HIV-1-infected adults. Volume 118 of Issue 3. The Journal of clinical investigation 2008. PMID: 18292808


  138. Malleret B, Karlsson I, Manéglier B, Brochard P, Delache B, Andrieu T, Muller-Trutwin M, Beaumont T, McCune JM, Banchereau J, Le Grand R, Vaslin B. Effect of SIVmac infection on plasmacytoid and CD1c+ myeloid dendritic cells in cynomolgus macaques. Immunology 2008. PMID: 18217951


  139. Hunt PW, Brenchley J, Sinclair E, McCune JM, Roland M, Page-Shafer K, Hsue P, Emu B, Krone M, Lampiris H, Douek D, Martin JN, Deeks SG. Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. Volume 197 of Issue 1. The Journal of infectious diseases 2008. PMID: 18171295


  140. Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune JM, Bredt BM, Stablein DM, Stock PG. HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes. Volume 8 of Issue 2. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007. PMID: 18093266


  141. Hartigan-O'Connor DJ, Abel K, McCune JM. Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. The Journal of experimental medicine 2007. PMID: 17954571


  142. Kanwar B, Gao DW, Hwang AB, Grenert JP, Williams SP, Franc B, McCune JM. In vivo imaging of mucosal CD4+ T cells using single photon emission computed tomography in a murine model of colitis. Journal of immunological methods 2007. PMID: 17964595


  143. Owen RE, Sinclair E, Emu B, Heitman JW, Hirschkorn DF, Epling CL, Tan QX, Custer B, Harris JM, Jacobson MA, McCune JM, Martin JN, Hecht FM, Deeks SG, Norris PJ. Loss of T cell responses following long-term cryopreservation. Volume 326 of Issue 1-2. Journal of immunological methods 2007. PMID: 17707394


  144. Miller CJ, Genescà M, Abel K, Montefiori D, Forthal D, Bost K, Li J, Favre D, McCune JM. Antiviral antibodies are necessary for control of simian immunodeficiency virus replication. Journal of virology 2007. PMID: 17329327


  145. Abrams DI, Shade SB, Couey P, McCune JM, Lo J, Bacchetti P, Chang B, Epling L, Liegler T, Grant RM. Dehydroepiandrosterone (DHEA) effects on HIV replication and host immunity: a randomized placebo-controlled study. Volume 23 of Issue 1. AIDS research and human retroviruses 2007. PMID: 17263636


  146. Hsue PY, Hunt PW, Sinclair E, Bredt B, Franklin A, Killian M, Hoh R, Martin JN, McCune JM, Waters DD, Deeks SG. Increased carotid intima-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses. Volume 20 of Issue 18. AIDS (London, England) 2006. PMID: 17117013


  147. Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. Volume 319 of Issue 1-2. Journal of immunological methods 2006. PMID: 17173927


  148. Baum PD, McCune JM. Direct measurement of T-cell receptor repertoire diversity with AmpliCot. Nature methods 2006. PMID: 17060913


  149. Ahuja SK, Aiuti F, Berkhout B, Biberfeld P, Burton DR, Colizzi V, Deeks SG, Desrosiers RC, Dierich MP, Doms RW, Emerman M, Gallo RC, Girard M, Greene WC, Hoxie JA, Hunter E, Klein G, Korber B, Kuritzkes DR, Lederman MM, Malim MH, Marx PA, McCune JM, McMichael A, Miller C, Miller V, Montagnier L, Montefiori DC, Moore JP, Nixon DF, Overbaugh J, Pauza CD, Richman DD, Saag MS, Sattentau Q, Schooley RT, Shattock R, Shaw GM, Stevenson M, Trkola A, Wainberg MA, Weiss RA, Wolinsky S, Zack JA. A plea for justice for jailed medical workers. Volume 314 of Issue 5801. Science (New York, N.Y.) 2006. PMID: 17062652


  150. Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. Volume 116 of Issue 10. The Journal of clinical investigation 2006. PMID: 16998586


  151. Hunt PW, Harrigan PR, Huang W, Bates M, Williamson DW, McCune JM, Price RW, Spudich SS, Lampiris H, Hoh R, Leigler T, Martin JN, Deeks SG. Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremia. Volume 194 of Issue 7. The Journal of infectious diseases 2006. PMID: 16960780


  152. Nomura LE, Emu B, Hoh R, Haaland P, Deeks SG, Martin JN, McCune JM, Nixon DF, Maecker HT. IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells. AIDS research and therapy 2006. PMID: 16859558


  153. Deeks SG, Schweighardt B, Wrin T, Galovich J, Hoh R, Sinclair E, Hunt P, McCune JM, Martin JN, Petropoulos CJ, Hecht FM. Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses. Volume 80 of Issue 12. Journal of virology 2006. PMID: 16731954


  154. Michaëlsson J, Mold JE, McCune JM, Nixon DF. Regulation of T cell responses in the developing human fetus. Journal of immunology (Baltimore, Md. : 1950) 2006. PMID: 16670279


  155. Papasavvas E, Kostman JR, Thiel B, Pistilli M, Mackiewicz A, Foulkes A, Gross R, Jordan KA, Nixon DF, Grant R, Poulin JF, McCune JM, Mounzer K, Montaner LJ. HIV-1-specific CD4+ T cell responses in chronically HIV-1 infected blippers on antiretroviral therapy in relation to viral replication following treatment interruption. Journal of clinical immunology 2006. PMID: 16418802


  156. Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. Literature watch. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. Lymphatic research and biology 2006. PMID: 17394406


  157. Napolitano LA, Burt TD, Bacchetti P, Barrón Y, French AL, Kovacs A, Anastos K, Young M, McCune JM, Greenblatt RM. Increased circulating interleukin-7 levels in HIV-1-infected women. Volume 40 of Issue 5. Journal of acquired immune deficiency syndromes (1999) 2005. PMID: 16284535


  158. Roy AM, Schweighardt B, Eckstein LA, Goldsmith MA, McCune JM. Enhanced replication of R5 HIV-1 over X4 HIV-1 in CD4(+)CCR5(+)CXCR4(+) T cells. Journal of acquired immune deficiency syndromes (1999) 2005. PMID: 16249699


  159. Emu B, Sinclair E, Favre D, Moretto WJ, Hsue P, Hoh R, Martin JN, Nixon DF, McCune JM, Deeks SG. Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. Volume 79 of Issue 22. Journal of virology 2005. PMID: 16254352


  160. Hanley MB, Napolitano LA, McCune JM. Growth hormone-induced stimulation of multilineage human hematopoiesis. Stem cells (Dayton, Ohio) 2005. PMID: 15955828


  161. Harris JM, Hazenberg MD, Poulin JF, Higuera-Alhino D, Schmidt D, Gotway M, McCune JM. Multiparameter evaluation of human thymic function: interpretations and caveats. Clinical immunology (Orlando, Fla.) 2005. PMID: 15885636


  162. Stone JH, Rajapakse VN, Hoffman GS, Specks U, Merkel PA, Spiera RF, Davis JC, St Clair EW, McCune J, Ross S, Hitt BA, Veenstra TD, Conrads TP, Liotta LA, Petricoin EF. A serum proteomic approach to gauging the state of remission in Wegener's granulomatosis. Arthritis and rheumatism 2005. PMID: 15751091


  163. Smith K, Aga E, Bosch RJ, Valdez H, Connick E, Landay A, Kuritzkes D, Gross BH, Francis IR, McCune JM, Kessler H, Lederman M. Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy. AIDS (London, England) 2004. PMID: 15353982


  164. Lee MS, Hanspers K, Barker CS, Korn AP, McCune JM. Gene expression profiles during human CD4+ T cell differentiation. International immunology 2004. PMID: 15210650


  165. Busch R, Cesar D, Higuera-Alhino D, Gee T, Hellerstein MK, McCune JM. Isolation of peripheral blood CD4(+) T cells using RosetteSep and MACS for studies of DNA turnover by deuterium labeling. Journal of immunological methods 2004. PMID: 15087225


  166. Burton DR, Desrosiers RC, Doms RW, Feinberg MB, Gallo RC, Hahn B, Hoxie JA, Hunter E, Korber B, Landay A, Lederman MM, Lieberman J, McCune JM, Moore JP, Nathanson N, Picker L, Richman D, Rinaldo C, Stevenson M, Watkins DI, Wolinsky SM, Zack JA. Public health. A sound rationale needed for phase III HIV-1 vaccine trials. Science (New York, N.Y.) 2004. PMID: 14726576


  167. Deeks SG, Martin JN, Sinclair E, Harris J, Neilands TB, Maecker HT, Hagos E, Wrin T, Petropoulos CJ, Bredt B, McCune JM. Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1. Volume 189 of Issue 2. The Journal of infectious diseases 2004. PMID: 14722897


  168. Karlsson AC, Martin JN, Younger SR, Bredt BM, Epling L, Ronquillo R, Varma A, Deeks SG, McCune JM, Nixon DF, Sinclair E. Comparison of the ELISPOT and cytokine flow cytometry assays for the enumeration of antigen-specific T cells. Volume 283 of Issue 1-2. Journal of immunological methods 2003. PMID: 14659906


  169. Jennings JE, Sundgren PC, Attwood J, McCune J, Maly P. Value of MRI of the brain in patients with systemic lupus erythematosus and neurologic disturbance. Neuroradiology 2003. PMID: 14648006


  170. Hellerstein MK, Hoh RA, Hanley MB, Cesar D, Lee D, Neese RA, McCune JM. Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection. The Journal of clinical investigation 2003. PMID: 12975480


  171. Abrams DI, Hilton JF, Leiser RJ, Shade SB, Elbeik TA, Aweeka FT, Benowitz NL, Bredt BM, Kosel B, Aberg JA, Deeks SG, Mitchell TF, Mulligan K, Bacchetti P, McCune JM, Schambelan M. Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial. Volume 139 of Issue 4. Annals of internal medicine 2003. PMID: 12965981


  172. Napolitano LA, Stoddart CA, Hanley MB, Wieder E, McCune JM. Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice. Volume 171 of Issue 2. Journal of immunology (Baltimore, Md. : 1950) 2003. PMID: 12847229


  173. Stoddart CA, Geleziunas R, Ferrell S, Linquist-Stepps V, Moreno ME, Bare C, Xu W, Yonemoto W, Bresnahan PA, McCune JM, Greene WC. Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis. Volume 77 of Issue 3. Journal of virology 2003. PMID: 12525647


  174. Neese RA, Misell LM, Turner S, Chu A, Kim J, Cesar D, Hoh R, Antelo F, Strawford A, McCune JM, Christiansen M, Hellerstein MK. Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA. Proceedings of the National Academy of Sciences of the United States of America 2002. PMID: 12424339


  175. Bredt BM, Higuera-Alhino D, Shade SB, Hebert SJ, McCune JM, Abrams DI. Short-term effects of cannabinoids on immune phenotype and function in HIV-1-infected patients. Volume 42 of Issue S1. Journal of clinical pharmacology 2002. PMID: 12412840


  176. Keir ME, Rosenberg MG, Sandberg JK, Jordan KA, Wiznia A, Nixon DF, Stoddart CA, McCune JM. Generation of CD3+CD8low thymocytes in the HIV type 1-infected thymus. Journal of immunology (Baltimore, Md. : 1950) 2002. PMID: 12193754


  177. Feinberg MB, McCune JM, Miedema F, Moore JP, Schuitemaker H. HIV tropism and CD4+ T-cell depletion. Nature medicine 2002. PMID: 12042782


  178. Napolitano LA, Lo JC, Gotway MB, Mulligan K, Barbour JD, Schmidt D, Grant RM, Halvorsen RA, Schambelan M, McCune JM. Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone. AIDS (London, England) 2002. PMID: 12004268


  179. Deeks SG, Hoh R, Grant RM, Wrin T, Barbour JD, Narvaez A, Cesar D, Abe K, Hanley MB, Hellmann NS, Petropoulos CJ, McCune JM, Hellerstein MK. CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy. The Journal of infectious diseases 2002. PMID: 11807713


  180. Keir ME, Stoddart CA, Linquist-Stepps V, Moreno ME, McCune JM. IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus. Volume 168 of Issue 1. Journal of immunology (Baltimore, Md. : 1950) 2002. PMID: 11751977


  181. Teixeira L, Valdez H, McCune JM, Koup RA, Badley AD, Hellerstein MK, Napolitano LA, Douek DC, Mbisa G, Deeks S, Harris JM, Barbour JD, Gross BH, Francis IR, Halvorsen R, Asaad R, Lederman MM. Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function. AIDS (London, England) 2001. PMID: 11579235


  182. Maecker HT, Dunn HS, Suni MA, Khatamzas E, Pitcher CJ, Bunde T, Persaud N, Trigona W, Fu TM, Sinclair E, Bredt BM, McCune JM, Maino VC, Kern F, Picker LJ. Use of overlapping peptide mixtures as antigens for cytokine flow cytometry. Journal of immunological methods 2001. PMID: 11470284


  183. Stoddart CA, Liegler TJ, Mammano F, Linquist-Stepps VD, Hayden MS, Deeks SG, Grant RM, Clavel F, McCune JM. Impaired replication of protease inhibitor-resistant HIV-1 in human thymus. Nature medicine 2001. PMID: 11385509


  184. McCune JM. The dynamics of CD4+ T-cell depletion in HIV disease. Nature 2001. PMID: 11309627


  185. Jacobson MA, Schrier R, McCune JM, Torriani FJ, Holland GN, O'Donnell JJ, Freeman WR, Bredt BM. Cytomegalovirus (CMV)-specific CD4+ T lymphocyte immune function in long-term survivors of AIDS-related CMV end-organ disease who are receiving potent antiretroviral therapy. The Journal of infectious diseases 2001. PMID: 11294673


  186. Komanduri KV, Feinberg J, Hutchins RK, Frame RD, Schmidt DK, Viswanathan MN, Lalezari JP, McCune JM. Loss of cytomegalovirus-specific CD4+ T cell responses in human immunodeficiency virus type 1-infected patients with high CD4+ T cell counts and recurrent retinitis. The Journal of infectious diseases 2001. PMID: 11262214


  187. Deeks SG, Wrin T, Liegler T, Hoh R, Hayden M, Barbour JD, Hellmann NS, Petropoulos CJ, McCune JM, Hellerstein MK, Grant RM. Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia. The New England journal of medicine 2001. PMID: 11172188


  188. Komanduri KV, Donahoe SM, Moretto WJ, Schmidt DK, Gillespie G, Ogg GS, Roederer M, Nixon DF, McCune JM. Direct measurement of CD4+ and CD8+ T-cell responses to CMV in HIV-1-infected subjects. Virology 2001. PMID: 11162802


  189. Komanduri KV, McCune JM. The diversity of T cells. The New England journal of medicine 2001. PMID: 11188843


  190. Napolitano LA, Grant RM, Deeks SG, Schmidt D, De Rosa SC, Herzenberg LA, Herndier BG, Andersson J, McCune JM. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nature medicine 2001. PMID: 11135619


  191. Gobbi A, Stoddart CA, Locatelli G, Santoro F, Bare C, Linquist-Stepps V, Moreno ME, Abbey NW, Herndier BG, Malnati MS, McCune JM, Lusso P. Coinfection of SCID-hu Thy/Liv mice with human herpesvirus 6 and human immunodeficiency virus type 1. Journal of virology 2000. PMID: 10954574


  192. Berkowitz RD, Alexander S, McCune JM. Causal relationships between HIV-1 coreceptor utilization, tropism, and pathogenesis in human thymus. AIDS research and human retroviruses 2000. PMID: 10933618


  193. Schlegel P, Beatty P, Halvorsen R, McCune J. Successful allogeneic bone marrow transplant in an HIV-1-positive man with chronic myelogenous leukemia. Journal of acquired immune deficiency syndromes (1999) 2000. PMID: 10969356


  194. Jenkins M, Keir M, McCune JM. A membrane-bound Fas decoy receptor expressed by human thymocytes. The Journal of biological chemistry 2000. PMID: 10713117


  195. Stoddart CA, Moreno ME, Linquist-Stepps VD, Bare C, Bogan MR, Gobbi A, Buckheit RW, Bedard J, Rando RF, McCune JM. Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice. Antimicrobial agents and chemotherapy 2000. PMID: 10681360


  196. McCune JM, Hanley MB, Cesar D, Halvorsen R, Hoh R, Schmidt D, Wieder E, Deeks S, Siler S, Neese R, Hellerstein M. Factors influencing T-cell turnover in HIV-1-seropositive patients. The Journal of clinical investigation 2000. PMID: 10712441


  197. Huang SS, Barbour JD, Deeks SG, Huang JS, Grant RM, Ng VL, McCune JM. Reversal of human immunodeficiency virus type 1-associated hematosuppression by effective antiretroviral therapy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000. PMID: 10722435


  198. Smith KY, Valdez H, Landay A, Spritzler J, Kessler HA, Connick E, Kuritzkes D, Gross B, Francis I, McCune JM, Lederman MM. Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy. The Journal of infectious diseases 2000. PMID: 10608760


  199. Dittmer D, Stoddart C, Renne R, Linquist-Stepps V, Moreno ME, Bare C, McCune JM, Ganem D. Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice. The Journal of experimental medicine 1999. PMID: 10601360


  200. Berkowitz RD, van't Wout AB, Kootstra NA, Moreno ME, Linquist-Stepps VD, Bare C, Stoddart CA, Schuitemaker H, McCune JM. R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus. Journal of virology 1999. PMID: 10438873


  201. Poulin JF, Viswanathan MN, Harris JM, Komanduri KV, Wieder E, Ringuette N, Jenkins M, McCune JM, Sékaly RP. Direct evidence for thymic function in adult humans. The Journal of experimental medicine 1999. PMID: 10449519


  202. Jenkins M, Keir M, McCune JM. Fas is expressed early in human thymocyte development but does not transmit an apoptotic signal. Journal of immunology (Baltimore, Md. : 1950) 1999. PMID: 10415014


  203. Gobbi A, Stoddart CA, Malnati MS, Locatelli G, Santoro F, Abbey NW, Bare C, Linquist-Stepps V, Moreno MB, Herndier BG, Lusso P, McCune JM. Human herpesvirus 6 (HHV-6) causes severe thymocyte depletion in SCID-hu Thy/Liv mice. The Journal of experimental medicine 1999. PMID: 10377191


  204. Kovalev G, Duus K, Wang L, Lee R, Bonyhadi M, Ho D, McCune JM, Kaneshima H, Su L. Induction of MHC class I expression on immature thymocytes in HIV-1-infected SCID-hu Thy/Liv mice: evidence of indirect mechanisms. Journal of immunology (Baltimore, Md. : 1950) 1999. PMID: 10358212


  205. Hellerstein M, Hanley MB, Cesar D, Siler S, Papageorgopoulos C, Wieder E, Schmidt D, Hoh R, Neese R, Macallan D, Deeks S, McCune JM. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nature medicine 1999. PMID: 9883844


  206. Berkowitz RD, Alexander S, Bare C, Linquist-Stepps V, Bogan M, Moreno ME, Gibson L, Wieder ED, Kosek J, Stoddart CA, McCune JM. CCR5- and CXCR4-utilizing strains of human immunodeficiency virus type 1 exhibit differential tropism and pathogenesis in vivo. Journal of virology 1998. PMID: 9811751


  207. Berkowitz RD, Beckerman KP, Schall TJ, McCune JM. CXCR4 and CCR5 expression delineates targets for HIV-1 disruption of T cell differentiation. Journal of immunology (Baltimore, Md. : 1950) 1998. PMID: 9759895


  208. Stoddart CA, Rabin L, Hincenbergs M, Moreno M, Linquist-Stepps V, Leeds JM, Truong LA, Wyatt JR, Ecker DJ, McCune JM. Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320. Antimicrobial agents and chemotherapy 1998. PMID: 9687417


  209. Komanduri KV, Viswanathan MN, Wieder ED, Schmidt DK, Bredt BM, Jacobson MA, McCune JM. Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1. Nature medicine 1998. PMID: 9701250


  210. McCune JM, Loftus R, Schmidt DK, Carroll P, Webster D, Swor-Yim LB, Francis IR, Gross BH, Grant RM. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. The Journal of clinical investigation 1998. PMID: 9616201


  211. Jenkins M, Hanley MB, Moreno MB, Wieder E, McCune JM. Human immunodeficiency virus-1 infection interrupts thymopoiesis and multilineage hematopoiesis in vivo. Blood 1998. PMID: 9531575


  212. Namikawa R, Kaneshima H, McCune JM. Furry flasks? Nature biotechnology 1998. PMID: 9555715


  213. Linquist V, Stoddart CA, McCune JM. UV irradiation of polystyrene pipets releases PCR inhibitors. BioTechniques 1998. PMID: 9454951


  214. McCune JM. Animal models of HIV-1 disease. Science (New York, N.Y.) 1997. PMID: 9432722


  215. McCune JM. Thymic function in HIV-1 disease. Seminars in immunology 1997. PMID: 9405269


  216. Hellerstein MK, McCune JM. T cell turnover in HIV-1 disease. Immunity 1997. PMID: 9390682


  217. Komanduri KV, Salha MD, Sékaly RP, McCune JM. Superantigen-mediated deletion of specific T cell receptor V beta subsets in the SCID-hu Thy/Liv mouse is induced by staphylococcal enterotoxin B, but not HIV-1. Journal of immunology (Baltimore, Md. : 1950) 1997. PMID: 8992966


  218. Su L, Kaneshima H, Bonyhadi ML, Lee R, Auten J, Wolf A, Du B, Rabin L, Hahn BH, Terwilliger E, Mccune JM. Identification of HIV-1 determinants for replication in vivo. Virology 1997. PMID: 9007057


  219. McCune JM. Development and applications of the SCID-hu mouse model. Seminars in immunology 1996. PMID: 8883141


  220. Auwaerter PG, Kaneshima H, McCune JM, Wiegand G, Griffin DE. Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosis. Journal of virology 1996. PMID: 8648708


  221. Datema R, Rabin L, Hincenbergs M, Moreno MB, Warren S, Linquist V, Rosenwirth B, Seifert J, McCune JM. Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry. Antimicrobial agents and chemotherapy 1996. PMID: 8851605


  222. Rabin L, Hincenbergs M, Moreno MB, Warren S, Linquist V, Datema R, Charpiot B, Seifert J, Kaneshima H, McCune JM. Use of standardized SCID-hu Thy/Liv mouse model for preclinical efficacy testing of anti-human immunodeficiency virus type 1 compounds. Antimicrobial agents and chemotherapy 1996. PMID: 8851606


  223. McCune JM. HIV and the cells it infects: sorting the latent from the labile. An interview with Mike McCune, MD, PhD. Interview by Mark Mascolini. Journal of the International Association of Physicians in AIDS Care 1996. PMID: 11363326


  224. Bonyhadi ML, Su L, Auten J, McCune JM, Kaneshima H. Development of a human thymic organ culture model for the study of HIV pathogenesis. AIDS research and human retroviruses 1995. PMID: 8554904


  225. McCune JM. Viral latency in HIV disease. Cell 1995. PMID: 7628009


  226. Su L, Kaneshima H, Bonyhadi M, Salimi S, Kraft D, Rabin L, McCune JM. HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo. Immunity 1995. PMID: 7600300


  227. Kaneshima H, Su L, Bonyhadi ML, Connor RI, Ho DD, McCune JM. Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse. Journal of virology 1994. PMID: 7966610


  228. Kaneshima H, Namikawa R, McCune JM. Human hematolymphoid cells in SCID mice. Current opinion in immunology 1994. PMID: 7912081


  229. Kyoizumi S, McCune JM, Namikawa R. Direct evaluation of radiation damage in human hematopoietic progenitor cells in vivo. Radiation research 1994. PMID: 7505456


  230. Epstein LG, Cvetkovich TA, Lazar ES, DiLoreto D, Saito Y, James H, del Cerro C, Kaneshima H, McCune JM, Britt WJ. Human neural xenografts: progress in developing an in-vivo model to study human immunodeficiency virus (HIV) and human cytomegalovirus (HCMV) infection. Advances in neuroimmunology 1994. PMID: 7874392


  231. Stanley SK, McCune JM, Kaneshima H, Justement JS, Sullivan M, Boone E, Baseler M, Adelsberger J, Bonyhadi M, Orenstein J. Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse. The Journal of experimental medicine 1993. PMID: 8376927


  232. Bonyhadi ML, Rabin L, Salimi S, Brown DA, Kosek J, McCune JM, Kaneshima H. HIV induces thymus depletion in vivo. Nature 1993. PMID: 8100043


  233. Mocarski ES, Bonyhadi M, Salimi S, McCune JM, Kaneshima H. Human cytomegalovirus in a SCID-hu mouse: thymic epithelial cells are prominent targets of viral replication. Proceedings of the National Academy of Sciences of the United States of America 1993. PMID: 7678330


  234. Kyoizumi S, Baum CM, Kaneshima H, McCune JM, Yee EJ, Namikawa R. Implantation and maintenance of functional human bone marrow in SCID-hu mice. Blood 1992. PMID: 1558966


  236. McCune JM, Péault B, Streeter PR, Rabin L. Preclinical evaluation of human hematolymphoid function in the SCID-hu mouse. Immunological reviews 1991. PMID: 1804780


  237. Péault B, Weissman IL, Baum C, McCune JM, Tsukamoto A. Lymphoid reconstitution of the human fetal thymus in SCID mice with CD34+ precursor cells. The Journal of experimental medicine 1991. PMID: 1719121


  238. Vandekerckhove BA, Krowka JF, McCune JM, de Vries JE, Spits H, Roncarolo MG. Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse. Journal of immunology (Baltimore, Md. : 1950) 1991. PMID: 1674954


  239. Krowka JF, Sarin S, Namikawa R, McCune JM, Kaneshima H. Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent. Journal of immunology (Baltimore, Md. : 1950) 1991. PMID: 1827814


  240. Kaneshima H, Shih CC, Namikawa R, Rabin L, Outzen H, Machado SG, McCune JM. Human immunodeficiency virus infection of human lymph nodes in the SCID-hu mouse. Proceedings of the National Academy of Sciences of the United States of America 1991. PMID: 1903543


  241. McCune JM. SCID mice as immune system models. Current opinion in immunology 1991. PMID: 2069748


  242. Shih CC, Kaneshima H, Rabin L, Namikawa R, Sager P, McGowan J, McCune JM. Postexposure prophylaxis with zidovudine suppresses human immunodeficiency virus type 1 infection in SCID-hu mice in a time-dependent manner. The Journal of infectious diseases 1991. PMID: 1995734


  243. McCune JM. HIV-1: the infective process in vivo. Cell 1991. PMID: 1988152


  244. McCune J, Kaneshima H, Krowka J, Namikawa R, Outzen H, Peault B, Rabin L, Shih CC, Yee E, Lieberman M. The SCID-hu mouse: a small animal model for HIV infection and pathogenesis. Annual review of immunology 1991. PMID: 1910684


  245. Kaneshima H, Baum C, Chen B, Namikawa R, Outzen H, Rabin L, Tsukamoto A, McCune JM. Today's SCID-hu mouse. Nature 1990. PMID: 2247165


  246. McCune JM, Namikawa R, Shih CC, Rabin L, Kaneshima H. Pseudotypes in HIV-infected mice. Science (New York, N.Y.) 1990. PMID: 2174574


  247. Namikawa R, Weilbaecher KN, Kaneshima H, Yee EJ, McCune JM. Long-term human hematopoiesis in the SCID-hu mouse. The Journal of experimental medicine 1990. PMID: 2212942


  248. McCune JM, Namikawa R, Shih CC, Rabin L, Kaneshima H. Suppression of HIV infection in AZT-treated SCID-hu mice. Science (New York, N.Y.) 1990. PMID: 2300816


  249. McCune JM, Kaneshima H, Rabin L, Shih CC, Namikawa R. Preclinical evaluation of antiviral compounds in the SCID-hu mouse. Annals of the New York Academy of Sciences 1990. PMID: 2078024


  250. McCune JM, Kaneshima H, Lieberman M, Weissman IL, Namikawa R. The scid-hu mouse: current status and potential applications. Current topics in microbiology and immunology 1989. PMID: 2680299


  251. Namikawa R, Kaneshima H, Lieberman M, Weissman IL, McCune JM. Infection of the SCID-hu mouse by HIV-1. Science (New York, N.Y.) 1988. PMID: 3201256


  252. McCune JM, Namikawa R, Kaneshima H, Shultz LD, Lieberman M, Weissman IL. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science (New York, N.Y.) 1988. PMID: 2971269


  253. McCune JM, Rabin LB, Feinberg MB, Lieberman M, Kosek JC, Reyes GR, Weissman IL. Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus. Cell 1988. PMID: 2450679


  254. Lieberman M, Hansteen GA, McCune JM, Scott ML, White JH, Weissman IL. Indirect induction of radiation lymphomas in mice. Evidence for a novel, transmissible leukemogen. The Journal of experimental medicine 1987. PMID: 3316475


  255. McCune JM, Fu SM. Ig biosynthesis in a human pre-B cell line. Journal of immunology (Baltimore, Md. : 1950) 1981. PMID: 6271874


  256. McCune JM, Fu SM, Kunkel HG. J chain biosynthesis in pre-B cells and other possible precursor B cells. The Journal of experimental medicine 1981. PMID: 6265589


  258. Fu SM, Hurley JN, McCune JM, Kunkel HG, Good RA. Pre-B cells and other possible precursor lymphoid cell lines derived from patients with X-linked agammaglobulinemia. The Journal of experimental medicine 1980. PMID: 6256462


  259. McCune JM, Lingappa VR, Fu SM, Blobel G, Kunkel HG. Biogenesis of membrane-bound and secreted immunoglobulins. I. Two distinct translation products of human mu-chain, with identical N-termini and different C-termini. The Journal of experimental medicine 1980. PMID: 6772735


  260. Yu DT, McCune JM, Fu SM, Winchester RJ, Kunkel HG. Two types of Ia-positive T cells. Synthesis and exchange of Ia antigens. The Journal of experimental medicine 1980. PMID: 6967943


  261. Humphreys RE, McCune JM, Chess L, Herrman HC, Malenka DJ, Mann DL, Parham P, Schlossman SF, Strominger JL. Isolation and immunologic characterization of a human. B-lymphocyte-specific, cell surface antigen. The Journal of experimental medicine 1976. PMID: 58959


  262. Strominger JL, Humphreys RE, McCune JM, Parham P, Robb R, Springer T, Terhorst C. The immunoglobulin-like structure of human histocompatibility antigens. Federation proceedings 1976. PMID: 57071


  263. McCune JM, Humphreys RE, Yocum RR, Strominger JL. Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus. Proceedings of the National Academy of Sciences of the United States of America 1975. PMID: 171657