Babak Javid, PhD, MB BChir

Associate Professor

I am an infectious diseases physician-scientist. My research focuses on three questions with regards to why/how tuberculosis is the world's most successful (and deadly) bacterial pathogen:

(1) how does regulation of bacterial protein synthesis allow mycobacteria to adapt to hostile environments.
(2) what is the role and mechanism of antibody-mediated immunity to tuberculosis.
(3) what the molecular mechanisms that allow Mycobacterium tuberculosis to survive antibiotics -- necessitating months-long treatment regimens.

I am always excited to explore new collaborations and work with people who are curious and passionate about making cool new discoveries, that may even be useful!
Education
09/2011 - Postdoctoral training, Harvard Chan School of Public Health
09/2007 - Infectious Diseases Fellowship, Cambridge University Hospitals
PhD, 05/2006 - Immunobiology, University of Cambridge
04/2001 - Internal Medicine Residency, Hammersmith & University College Hospitals
MB BChir, 12/1997 - Medicine and Surgery, University of Cambridge Clinical School
BA, 06/1995 - Medical Sciences, Psychology & Neurobiology, University of Cambridge
Honors and Awards
  • Investigator, Wellcome Trust, 2017---
  • Young Immunologist of the Year, British Society for Immunology, 2003
Websites
Publications
  1. Fazel S, Zhang L, Javid B, Brikell I, Chang Z. Harnessing Twitter data to survey public attention and attitudes towards COVID-19 vaccines in the UK. 2021. PMID: 34907201


  2. Divangahi M, Javid B, Kaufmann E. 100 years of antibody solitude in TB. 2021. PMID: 34811545


  3. Li YY, Cai RJ, Yang JY, Hendrickson TL, Xiang Y, Javid B. Clinically Relevant Mutations of Mycobacterial GatCAB Inform Regulation of Translational Fidelity. 2021. PMID: 34225495


  4. Javid B, Bassler D, Bryant MB, Cevik M, Tufekci Z, Baral S. Should masks be worn outdoors? 2021. PMID: 33910914


  5. Vijay S, Nhung HN, Bao NLH, Thu DDA, Trieu LPT, Phu NH, Thwaites GE, Javid B, Thuong NTT. Most-Probable-Number-Based Minimum Duration of Killing Assay for Determining the Spectrum of Rifampicin Susceptibility in Clinical Mycobacterium tuberculosis Isolates. 2021. PMID: 33257450


  6. Watson A, Li H, Ma B, Weiss R, Bendayan D, Abramovitz L, Ben-Shalom N, Mor M, Pinko E, Bar Oz M, Wang Z, Du F, Lu Y, Rybniker J, Dahan R, Huang H, Barkan D, Xiang Y, Javid B, Freund NT. Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis. 2021. PMID: 33504803


  7. Beaudry G, Zhong S, Whiting D, Javid B, Frater J, Fazel S. Managing outbreaks of highly contagious diseases in prisons: a systematic review. 2020. PMID: 33199278


  8. Chen YX, Xu ZY, Ge X, Sanyal S, Lu ZJ, Javid B. Selective translation by alternative bacterial ribosomes. 2020. PMID: 32723820


  9. Chen Y, Sun T, Bi Z, Ni JQ, Pastor-Pareja JC, Javid B. Premature termination codon readthrough in Drosophila varies in a developmental and tissue-specific manner. 2020. PMID: 32444687


  10. Javid B, Weekes MP, Matheson NJ. Covid-19: should the public wear face masks? 2020. PMID: 32273278


  11. Zhang YW, Zhu JH, Wang ZQ, Wu Y, Meng X, Zheng X, Javid B. HspX promotes the polar localization of mycobacterial protein aggregates. 2019. PMID: 31601950


  12. Wu J, Mu R, Sun M, Zhao N, Pan M, Li H, Dong Y, Sun Z, Bai J, Hu M, Nathan CF, Javid B, Liu G. Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis. 2019. PMID: 31016962


  13. Zhu JH, Wang BW, Pan M, Zeng YN, Rego H, Javid B. Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription. 2018. PMID: 30310059


  14. Chen YX, Javid B. More than merely drug resistance. 2018. PMID: 30254331


  15. Li H, Javid B. Antibodies and tuberculosis: finally coming of age? 2018. PMID: 29872140


  16. Edwards D, Kent D, Lester C, Brown CS, Murphy ME, Brown NM, Sule O, Itani A, Chand M, Trindall A, Pearson C, Roddick I, Fry NK, Hoffmann J, Iyanger N, Kemp L, White J, Javid B, Ramsay ID, Zenner D, Ahmed A, Amirthalingam G, Salimee S, Litt D, Reacher M. Transmission of toxigenic Corynebacterium diphtheriae by a fully immunised resident returning from a visit to West Africa, United Kingdom, 2017. 2018. PMID: 30280689


  17. Chaudhuri S, Li L, Zimmerman M, Chen Y, Chen YX, Toosky MN, Gardner M, Pan M, Li YY, Kawaji Q, Zhu JH, Su HW, Martinot AJ, Rubin EJ, Dartois VA, Javid B. Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation. 2018. PMID: 30152756


  18. Li H, Wang XX, Wang B, Fu L, Liu G, Lu Y, Cao M, Huang H, Javid B. Latently and uninfected healthcare workers exposed to TB make protective antibodies against Mycobacterium tuberculosis. 2017. PMID: 28438994


  19. Su HW, Zhu JH, Li H, Cai RJ, Ealand C, Wang X, Chen YX, Kayani MU, Zhu TF, Moradigaravand D, Huang H, Kana BD, Javid B. The essential mycobacterial amidotransferase GatCAB is a modulator of specific translational fidelity. 2016. PMID: 27564922


  20. Long J, Basu Roy R, Zhang YJ, Antrobus R, Du Y, Smith DL, Weekes MP, Javid B. Plasma Membrane Profiling Reveals Upregulation of ABCA1 by Infected Macrophages Leading to Restriction of Mycobacterial Growth. 2016. PMID: 27462310


  21. Moradigaravand D, Grandjean L, Martinez E, Li H, Zheng J, Coronel J, Moore D, Török ME, Sintchenko V, Huang H, Javid B, Parkhill J, Peacock SJ, Köser CU. dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains. 2016. PMID: 27021327


  22. Liu C, Kong C, Wu G, Zhu J, Javid B, Qian F. Uniform and amorphous rifampicin microspheres obtained by freezing induced LLPS during lyophilization. 2015. PMID: 26383842


  23. Zhu JH, Javid B. Tuberculosis: hey there, lonely guy! 2015. PMID: 25794612


  24. Köser CU, Javid B, Liddell K, Ellington MJ, Feuerriegel S, Niemann S, Brown NM, Burman WJ, Abubakar I, Ismail NA, Moore D, Peacock SJ, Török ME. Drug-resistance mechanisms and tuberculosis drugs. 2015. PMID: 25706840


  25. Ribas de Pouplana L, Santos MA, Zhu JH, Farabaugh PJ, Javid B. Protein mistranslation: friend or foe? 2014. PMID: 25023410


  26. Wang X, Li H, Jiang G, Zhao L, Ma Y, Javid B, Huang H. Prevalence and drug resistance of nontuberculous mycobacteria, northern China, 2008-2011. 2014. PMID: 24959839


  27. Javid B, Sorrentino F, Toosky M, Zheng W, Pinkham JT, Jain N, Pan M, Deighan P, Rubin EJ. Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance. 2014. PMID: 24395793


  28. Wong SY, Javid B, Addepalli B, Piszczek G, Strader MB, Limbach PA, Barry CE. Functional role of methylation of G518 of the 16S rRNA 530 loop by GidB in Mycobacterium tuberculosis. 2013. PMID: 24100503


  29. La Rosa V, Poce G, Canseco JO, Buroni S, Pasca MR, Biava M, Raju RM, Porretta GC, Alfonso S, Battilocchio C, Javid B, Sorrentino F, Ioerger TR, Sacchettini JC, Manetti F, Botta M, De Logu A, Rubin EJ, De Rossi E. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. 2011. PMID: 22024828


  30. Javid B, Derbyshire KM. Nanotubes: shaking hands, talking, or sharing? 2011. PMID: 21833333


  31. Su Y, Blake-Palmer KG, Sorrell S, Javid B, Bowers K, Zhou A, Chang SH, Qamar S, Karet FE. Human H+ATPase a4 subunit mutations causing renal tubular acidosis reveal a role for interaction with phosphofructokinase-1. 2008. PMID: 18632794


  32. Daly ML, Cartwright DJ, Lehner PJ, Javid B. A 58-year-old woman with abdominal symptoms and elevated C-reactive protein. 2008. PMID: 18597553


  33. Phuah CL, Javid B, Aliyu SH, Lever AM. A case of Mycoplasma hominis septic arthritis postpartum. 2007. PMID: 17892899


  34. Javid B, MacAry PA, Lehner PJ. Structure and function: heat shock proteins and adaptive immunity. 2007. PMID: 17675458


  35. Javid B, Aliyu SH, Save VE, Carmichael AJ, Lever AM. Schistosomal colonic polyposis in an HIV-positive man. 2007. PMID: 17255754


  36. Javid B, MacAry PA, Oehlmann W, Singh M, Lehner PJ. Peptides complexed with the protein HSP70 generate efficient human cytolytic T-lymphocyte responses. 2004. PMID: 15270691


  37. Watkins NA, Dafforn TR, Kuijpers M, Brown C, Javid B, Lehner PJ, Navarrete C, Ouwehand WH. Molecular studies of anti-HLA-A2 using light-chain shuffling: a structural model for HLA antibody binding. 2004. PMID: 15009806


  38. MacAry PA, Javid B, Floto RA, Smith KG, Oehlmann W, Singh M, Lehner PJ. HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation. 2004. PMID: 14738768


  39. Moore DA, Lightstone L, Javid B, Friedland JS. High rates of tuberculosis in end-stage renal failure: the impact of international migration. 2002. PMID: 11749753