Emerging infectious diseases
Authors: Moore DA, Lightstone L, Javid B, Friedland JS
Clinical and diagnostic laboratory immunology
Authors: Essajee SM, Yogev R, Pollack H, Greenhouse B, Krasinski K, Borkowsky W
Journal of immunology (Baltimore, Md. : 1950) | Volume 168 of Issue 1
Authors: Keir ME, Stoddart CA, Linquist-Stepps V, Moreno ME, McCune JM
The ability of HIV-1 to evade the host immune response leads to the establishment of chronic infection. HIV-1 has been reported to up-regulate MHC I molecules on the surface of thymocytes from HIV-1-infected thymus. We demonstrate in this study that HIV-1 up-regulates MHC I on both HIV-1-infected and uninfected thymocytes in a manner that is independent of Nef, proportional to viral replication, and entirely mediated by IFN-alpha. IL-3Ralpha+ type 2 predendritic cells (preDC2) resident in the thymic medulla secrete IFN-alpha, which acts on IFN-alphabetaR-expressing immature thymocytes to induce MHC I expression. Furthermore, thymic preDC2 are permissive for HIV-1 infection and positive for intracellular p24. These data demonstrate the ability of IFN-alpha secreted by preDC2 to induce MHC I up-regulation in the HIV-1-infected human thymus.
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Journal of virology
Authors: Ortiz GM, Hu J, Goldwitz JA, Chandwani R, Larsson M, Bhardwaj N, Bonhoeffer S, Ramratnam B, Zhang L, Markowitz MM, Nixon DF
Emerging infectious diseases
Authors: Moore DA, Lightstone L, Javid B, Friedland JS
Clinical and diagnostic laboratory immunology
Authors: Essajee SM, Yogev R, Pollack H, Greenhouse B, Krasinski K, Borkowsky W
The Journal of biological chemistry
Authors: Tone M, Tone Y, Babik JM, Lin CY, Waldmann H
Proceedings of the National Academy of Sciences of the United States of America
Authors: Ortiz GM, Wellons M, Brancato J, Vo HT, Zinn RL, Clarkson DE, Van Loon K, Bonhoeffer S, Miralles GD, Montefiori D, Bartlett JA, Nixon DF
Proceedings of the National Academy of Sciences of the United States of America
Authors: Strizki JM, Xu S, Wagner NE, Wojcik L, Liu J, Hou Y, Endres M, Palani A, Shapiro S, Clader JW, Greenlee WJ, Tagat JR, McCombie S, Cox K, Fawzi AB, Chou CC, Pugliese-Sivo C, Davies L, Moreno ME, Ho DD, Trkola A, Stoddart CA, Moore JP, Reyes GR, Baroudy BM
Journal of immunological methods
Authors: Maecker HT, Dunn HS, Suni MA, Khatamzas E, Pitcher CJ, Bunde T, Persaud N, Trigona W, Fu TM, Sinclair E, Bredt BM, McCune JM, Maino VC, Kern F, Picker LJ
